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Full-Text Articles in Physical Sciences and Mathematics
Polyisobutylene-Paclitaxel Conjugates With Pendant Carboxylic Acids And Polystyrene Chains: Towards Multifunctional Stent Coatings With Slow Drug Release, John F. Trant, Mahmoud M. Abd Rabo Moustafa, Inderpreet Sran, Elizabeth R. Gillies
Polyisobutylene-Paclitaxel Conjugates With Pendant Carboxylic Acids And Polystyrene Chains: Towards Multifunctional Stent Coatings With Slow Drug Release, John F. Trant, Mahmoud M. Abd Rabo Moustafa, Inderpreet Sran, Elizabeth R. Gillies
Chemistry and Biochemistry Publications
Drug-eluting stents are used in the treatment of atherosclerosis, where the incorporation of anti-proliferative or anti-inflammatory drugs decreases the rate of restenosis, the recurrence of artery narrowing. However, these stents can suffer from limitations such as drug depletion and delamination of the drug-eluting coating from the stent surface. Described here is an approach aimed at addressing these issues. Starting from a maleic anhydride adduct of polyisobutylene (PIB) prepared from butyl rubber, ring opening using paclitaxel (PTX) or a combination of PTX and polystyrene (PS) afforded covalent conjugates of PTX and PIB or PIB-PS graft copolymers bearing pendant carboxylic acids. When …