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Role Of Outer Membrane Permeability, Efflux Mechanism, And Carbapenemases In Carbapenem-Nonsusceptible Pseudomonas Aeruginosa From Dubai Hospitals: Results Of The First Cross-Sectional Survey, Carole Ayoub Moubareck, Dalal Hammoudi Halat, Charbel Akkawi, Anju Nabi, Mouza A. Alsharhan, Zulfa O. Aldeesi, Christabel C. Peters, Handan Celiloglu, Dolla Karam Sarkis
Role Of Outer Membrane Permeability, Efflux Mechanism, And Carbapenemases In Carbapenem-Nonsusceptible Pseudomonas Aeruginosa From Dubai Hospitals: Results Of The First Cross-Sectional Survey, Carole Ayoub Moubareck, Dalal Hammoudi Halat, Charbel Akkawi, Anju Nabi, Mouza A. Alsharhan, Zulfa O. Aldeesi, Christabel C. Peters, Handan Celiloglu, Dolla Karam Sarkis
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© 2019 The Authors Objectives: Carbapenem resistance in Pseudomonas aeruginosa is growing and results from variable mechanisms. The objectives of the current study were to investigate mechanisms of carbapenem resistance and genetic relatedness of P. aeruginosa isolates recovered in Dubai hospitals. Methods: From June 2015 through June 2016, carbapenem-nonsusceptible P. aeruginosa were collected from 4 hospitals in Dubai, and subjected to antimicrobial susceptibility testing, molecular investigation of carbapenemases by PCR-sequencing, analysis of outer membrane porin OprD2 and multidrug efflux channel MexAB-OprM levels by qPCR, and fingerprinting by ERIC-PCR. Results: Out of 1969 P. aeruginosa isolated during the study period, 471 …