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Articles 1 - 5 of 5
Full-Text Articles in Physical Sciences and Mathematics
Nbpmf: Novel Network-Based Inference Methods For Peptide Mass Fingerprinting, Zhewei Liang
Nbpmf: Novel Network-Based Inference Methods For Peptide Mass Fingerprinting, Zhewei Liang
Electronic Thesis and Dissertation Repository
Proteins are large, complex molecules that perform a vast array of functions in every living cell. A proteome is a set of proteins produced in an organism, and proteomics is the large-scale study of proteomes. Several high-throughput technologies have been developed in proteomics, where the most commonly applied are mass spectrometry (MS) based approaches. MS is an analytical technique for determining the composition of a sample. Recently it has become a primary tool for protein identification, quantification, and post translational modification (PTM) characterization in proteomics research. There are usually two different ways to identify proteins: top-down and bottom-up. Top-down approaches …
Modelling Walleye Population And Its Cannibalism Effect, Quan Zhou
Modelling Walleye Population And Its Cannibalism Effect, Quan Zhou
Electronic Thesis and Dissertation Repository
Walleye is a very common recreational fish in Canada with a strong cannibalism tendency, such that walleyes with larger sizes will consume their smaller counterparts when food sources are limited or a surplus of adults is present. Cannibalism may be a factor promoting population oscillation. As fish reach a certain age or biological stage (i.e. biological maturity), the number of fish achieving that stage is known as fish recruitment. The objective of this thesis is to model the walleye population with its recruitment and cannibalism effect. A matrix population model has been introduced to characterize the walleye population into three …
On Honey Bee Colony Dynamics And Disease Transmission, Matthew I. Betti
On Honey Bee Colony Dynamics And Disease Transmission, Matthew I. Betti
Electronic Thesis and Dissertation Repository
The work herein falls under the umbrella of mathematical modeling of disease transmission. The majority of this document focuses on the extent to which infection undermines the strength of a honey bee colony. These studies extend from simple mass-action ordinary differential equations models, to continuous age-structured partial differential equation models and finally a detailed agent-based model which accounts for vector transmission of infection between bees as well as a host of other influences and stressors on honey bee colony dynamics. These models offer a series of predictions relevant to the fate of honey bee colonies in the presence of disease …
Signet: A Neural Network Architecture For Predicting Protein-Protein Interactions, Muhammad S. Ahmed
Signet: A Neural Network Architecture For Predicting Protein-Protein Interactions, Muhammad S. Ahmed
Electronic Thesis and Dissertation Repository
The study of protein-protein interactions (PPI) is critically important within the field of Molecular Biology, as proteins facilitate key organismal functions including the maintenance of both cellular structure and function. Current experimental methods for elucidating PPIs are greatly hindered by large operating costs, lengthy wait times, as well as low accuracy. The recent development of computational PPI predicting techniques has worked to address many of these issues. Despite this, many of these methods utilize over-engineered features and naive learning algorithms. With the recent advances in Machine Learning and Artificial Intelligence, we attempt to view this problem through a novel, deep …
Metalation And Structural Properties Of Apo-Metallothioneins, Gordon W. Irvine
Metalation And Structural Properties Of Apo-Metallothioneins, Gordon W. Irvine
Electronic Thesis and Dissertation Repository
Metals are required by a quarter of all proteins to achieve their biological function, whether in an active site involved in catalytic chemistry or in a structural capacity. Metals are tightly regulated at the cellular level due to their propensity to cause unwanted side reactions and to be scavenged for use by pathogens. One of the proteins involved in this regulation of metal homeostasis is metallothionein (MT) which is a small, cysteine rich protein primarily involved in the regulation of zinc and copper homeostasis and heavy metal detoxification. MT is unique in its high cysteine content (~30% of the residues), …