Physical Sciences and Mathematics Commons^™

How We’Ll Fight The Next Deadly Virus Ted Talk Annotated Resource List, Susie Roy

Undergraduate Research Award

No abstract provided.

Your Body Language Shapes Who You Are Ted Talk Annotated Resource List, Elizabeth Hurm

Undergraduate Research Award

No abstract provided.

Dispersion Of Ammonia From Concentrated Animal Feeding Operations, Austin D. Wardall

Masters Theses & Specialist Projects

The purpose of this research is to investigate the dispersion of ammonia (NH3) from three Concentrated Animal Feeding Operations (CAFOs) in western Kentucky, as well as to investigate the Weather Research and Forecasting – Chemistry (WRF-Chem) model’s sensitivity response to initial NH3 concentrations under both wet conditions (significant precipitation) and dry conditions (no precipitation). As expected, pollutant concentrations generally were significantly higher near their points of origin and generally declined away from the sources. Contrary to expectations, ammonia tended to rise through the planetary boundary layer (PBL) regardless of atmospheric conditions. Results showed modeled NH3 pollution levels at the surface …

The Effects Of Sulfuric Acid Deposition On The Growth And Development Of Pond Breeding Salamanders In The Genus Ambystoma, Kenneth J. Anderson

Masters Theses & Specialist Projects

In terrestrial habitats with a history of mining activity and previous or ongoing reclamation efforts, understanding the effects of acidification on the ecology of amphibians is an important part of the restoration process and the conservation of local amphibian populations. Pond-breeding amphibians spend much of their post metamorphic life history in direct contact with the soil in upland habitat adjacent to aquatic breeding sites. I reared recently metamorphosed marbled salamanders (Ambystoma opacum) to evaluate the role of soil acidity on determinants of fitness such as growth and survival. My results indicate that a substrate of pH 4 was lethal to …

Development Of Dihydrochalcone Functionalized Gold Nanoparticles For Augmented Antineoplastic Activity, Jason N. Payne

Masters Theses & Specialist Projects

Phloridzin, an antidiabetic and antineoplastic agent usually found in fruit trees, is a dihydrochalcone constituent that has a clinical/pharmaceutical significance as a sodiumglucose linked transport 2 (SGLT2) inhibitor. Phloridzin never experienced widespread clinical usage in the pharmaceutical market due to its side effects and poor bioavailability when compared to other antidiabetic therapeutics. The poor bioavailability is primarily attributed to the degradation of the glycosidic bond of the phloridzin, resulting in the formation of phloretin, the aglycone of phloridzin and glucose. While phloretin displays a reduced capacity of SGLT2 inhibition, this nutraceutical shows enhanced antineoplastic activity in comparison to phloridzin. Gold …

Visible-Light Generation Of High-Valent Metal-Oxo Intermediates And A Biomimetic Oxidation Catalyzed By Manganese Porphyrins With Iodobenzene Diacetate, Ka Wai Kwong

Masters Theses & Specialist Projects

High-valent iron-oxo intermediates play central roles as active oxidants in enzymatic and synthetic catalytic oxidations. Many transition metal catalysts are designed for biomimetic studies of the predominant oxidation catalysts in Nature, the cytochrome P450 enzymes.

In this work, a new photochemical method to generate high-valent iron-oxo porphyrin models was discovered. As controlled by the electronic nature of porphyrin ligands, iron(IV)-oxo porphyrin radical cations (Compound I model) and iron(IV)-oxo porphyrin derivatives (Compound II model) were produced. These observations indicate that the photochemical reactions involve a heterolytic cleavage of O-Br in precursors to give a putative iron(V)-oxo intermediate, which might relax to …

Manufacturing And Engineering [Career Paper], Mahdi Alawami

Undergraduate Research Award

No abstract provided.

Multiplexed Detection Of Double-Stranded Pathogenic Dna With Engineered Zinc Finger Proteins, Juhwa Kim

Masters Theses & Specialist Projects

The development of a new technology for the detection of doublestranded (ds) DNA enables multiple biomedical applications including identifying multiple pathogens simultaneously. We previously employed colorimetric SEquence-Enabled Reassembly with TEM-1 β-lacatamase (SEER-LAC) to detect specific bacterial DNA sequence. SEER-Lac consists of the two inactive β-lactamase fragments which of each attached to a zinc finger protein (ZFP) would reassemble into an active full-length enzyme upon ZFPs binding to its target DNA. Here, we engineered two pairs of ZFPs which of each recognizes shiga toxin in E. coli O157 and staphylococcal enterotoxin B in Staphylococus Aureus, respectively. Biotin was simply conjugated to …

Evaluating The Influences Of Karst Hydrogeology On Freshwater Harmful Algal Blooms In Kentucky Lakes, Robert T. Schaefer

Masters Theses & Specialist Projects

A problem exists in Nolin River Lake and Rough River Lake in Kentucky, due to the increasing prevalence of cyanobacterial-based harmful algal blooms (CyanoHABs) and the threats they pose to local communities. These lakes were developed as artificial reservoirs from embankment. Further complicating the issue, the lakes are located within a heavily karstified region and there exists no plan or method currently for monitoring or managing CyanoHABs in a karst region with regard to groundwater inputs to the lake systems or their tributaries. A mixture of techniques and analysis methods was used to determine the best way to monitor and …

Using Zinc Finger Proteins As A Diagnostic Tool For The Detection Of A Cancer Biomarker, Anu Kini

Masters Theses & Specialist Projects

RASSF1A is a tumor suppressor gene which loses its function due to methylation of CpG islands on its promoter region. Detection of methylation leads to early diagnosis of cancer.

Zinc finger proteins are capable of detecting a specific DNA sequence and Methyl binding domain can bind to the methyl group on the CpG, using this idea mCpG SEER- Lac system makes use of a split protein, β-lactamase. Lac A attached to the ZFP and Lac B attached to the MBD protein. On binding to the DNA, the Lac A and Lac B come in close proximity with each other causing …

Synthetic Investigation On The Biomimetic Metal-Catalyzed Sulfoxidations And Photochemical Generation Of A Highly Reactive Ruthenium(V)-Oxo Porphyrin, Weilong Luo

Masters Theses & Specialist Projects

Catalytic oxidation plays a crucial role in current chemical and pharmaceutical industries which is also a leading technology for green chemical processes. In Nature, the ubiquitous cytochrome P450 enzymes can catalyze a wide variety of oxidation reactions with high efficiency and selectivity. Many transition metal catalysts are designed as the biomimetic model of cytochrome P450 enzymes. In this work, series of metalloporphyrins and metallocorroles have been successfully synthesized to investigate and develop catalytic selective oxidation of sulfides to sulfoxides.

Manganese(III) porphyrin complexes (2) and manganese(III) corrole complexes (6) with iodobenzene diacetate [PhI(OAc)2] as a mild oxygen source exhibited remarkable catalytic …

Undergraduate Research Projects Help Promote Diversity In The Geosciences, De'etra Young, Shannon R. Trimboli, Rick S. Toomey, Thomas Byl

Mammoth Cave Research Symposia

No abstract provided.

Citizen Science At Mammoth Cave National Park: Integrating Research And Education, Shannon R. Trimboli

Mammoth Cave Research Symposia

No abstract provided.

Modeling Activity Of The Indiana Bat (Myotis Sodalis) At Mammoth Cave National Park Using Remotely-Sensed Descriptors Of Forest Canopy Conditions, Luke E. Dodd, N, S. Skowronski, M. B. Dickinson, L. K. Rieske, M. J. Lacki

Mammoth Cave Research Symposia

No abstract provided.

Quantitative Dye Studies To Evaluate The Spill Response System For Mammoth Cave National Park, Jetara Brown, Thomas Byl, Rick S. Toomey, Lonnie Sharpe Jr.

Mammoth Cave Research Symposia

No abstract provided.

Natural Resource Condition Assessment For Mammoth Cave National Park, Cate Webb, Chris Groves, Katie Algeo

Mammoth Cave Research Symposia

No abstract provided.

The Max Kämper Map Of Mammoth Cave: An Nps Centennial Restoration, Tres Seymour

Mammoth Cave Research Symposia

No abstract provided.

What Data Analytics Can Do For You!, Leyla Zhuhadar, J. Kirk Atkinson, Albert Meier, Ouida Meier

Mammoth Cave Research Symposia

No abstract provided.

Use Of Multiphysics Simulation To Model Environmental Conditions Associated With Bat Hibernacula Including Preliminary Indication Of Impacts On Saltpeter Vats In Mammoth Cave, Aaron Bird, Rick Olson, Rick Toomey, Aaron Addison, Rachel Bosch

Mammoth Cave Research Symposia

No abstract provided.

The Effect Of Faulting On Past And Present Hydrogeology In Long Cave, Mammoth Cave National Park, Rick Olson, Rick S. Toomey

Mammoth Cave Research Symposia

No abstract provided.

An Overview Of The Reverse Flow Patterns Of River Styx In Mammoth Cave, Kentucky: 2009-2012, Shannon R. Trimboli, Kim Weber, Susan Ryan, Rick S. Toomey

Mammoth Cave Research Symposia

No abstract provided.

Measurement Of Inorganic Carbon Fluxes From Large River Basins In South Central Kentucky Karst, Connor Salley, Chris Groves

Mammoth Cave Research Symposia

No abstract provided.

Tracing Carbon In Karst Environments In South-Central Kentucky To Identify Changes In Groundwater Dynamic Under Varying Land Uses, Chelsea Ballard, Jason Polk, Kegan Mcclanahan

Mammoth Cave Research Symposia

No abstract provided.

Ongoing Geographic Documentation Of The Mammoth Cave System And Related Caves, Pat Kambesis, Bob Osburn

Mammoth Cave Research Symposia

No abstract provided.

Strip Adaptive Cluster Sampling With Application To Cave Crickets, Kurt Lewis Helf, Tom Philippi, Bill Moore, Lillian Scoggins

Mammoth Cave Research Symposia

No abstract provided.

Organization And Development Of The Eyes Of Ptomaphagus Hirtus, The Troglobitic Small Carrion Beetle Of Mammoth Cave, Markus Friedrich, Jasmina Kulacic, Elke Buschbeck

Mammoth Cave Research Symposia

No abstract provided.

Evaluating The Energetic Value Of Lepidoptera Using Bomb Calorimetry, Shelby A. Fulton, Luke E. Dodd, Lynne K. Rieske

Mammoth Cave Research Symposia

No abstract provided.

Summary Of 2015 Winter Bat Monitoring At Mammoth Cave National Park, Laura Shultz, Chris Clark, Rick Toomey, Shannon Trimboli

Mammoth Cave Research Symposia

No abstract provided.

The Activity Of Myotis Sodalis And Myotis Septentrionalis Changes On The Landscape Of Mammoth Cave National Park Following The Arrival Of White-Nose Syndrome, Rachael Griffitts, Luke E. Dodd, Michael J. Lacki

Mammoth Cave Research Symposia

No abstract provided.

Video Presentation: Monitoring Cave Organisms, Cumberland Piedmont Inventory And Monitoring Network, Kurt Helf, Steven Thomas, Michael Durham

Mammoth Cave Research Symposia

No abstract provided.