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Full-Text Articles in Physical Sciences and Mathematics
Giving Preparative Thin-Layer Chromatography Some Tender Loving Care, John J. Hayward, Lavleen Mader, John F. Trant
Giving Preparative Thin-Layer Chromatography Some Tender Loving Care, John J. Hayward, Lavleen Mader, John F. Trant
Chemistry and Biochemistry Publications
Preparative thin-layer chromatography (prepTLC) is a commonly used method of purification suitable for small-scale reactions. However, descriptions of the preferred methodology to load, run, and recover samples from prepTLC are non-standard and varied, making it part of the ‘hidden curriculum’ of laboratory techniques. In this article we report on the simple, cost-effective methods we use to load and collect samples from a plate, which enhance the convenience, speed, and precision of this technique.