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Engineering Proteins With Unique Characteristics For Diagnostics And Biosensors, Smita Joel
Engineering Proteins With Unique Characteristics For Diagnostics And Biosensors, Smita Joel
University of Kentucky Doctoral Dissertations
Proteins possess a broad range of structural and functional properties and, therefore, can be employed in a variety of biomedical applications. While a good number of protein-based biosensing systems and biosensors for target analytes have been developed, the search for versatile, highly sensitive and selective sensors with long term stability able to provide fast detection of target analytes continues to be a challenge. To that end, we now report the design and development of modified proteins with tailored characteristics and their further utilization in the development of biosensing systems.
We take advantage of binding proteins that undergo a change in …