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Electron Crystallography Of Aquaporins, Simeon Andrews, Steve Reichow, Tamir Gonen
Electron Crystallography Of Aquaporins, Simeon Andrews, Steve Reichow, Tamir Gonen
Chemistry Faculty Publications and Presentations
Aquaporins are a family of ubiquitous membrane proteins that form a pore for the permeation of water. Both electron and X-ray crystallography played major roles in determining the atomic structures of a number of aquaporins. This review focuses on electron crystallography, and its contribution to the field of aquaporin biology. We briefly discuss electron crystallography and the two-dimensional crystallization process. We describe features of aquaporins common to both electron and X-ray crystallographic structures; as well as some structural insights unique to electron crystallography, including aquaporin junction formation and lipid-protein interactions.