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Full-Text Articles in Physical Sciences and Mathematics
An Embarrassment Of Riches: The Enzymology Of Rna Modification, Dirk Iwata-Reuyl
An Embarrassment Of Riches: The Enzymology Of Rna Modification, Dirk Iwata-Reuyl
Chemistry Faculty Publications and Presentations
The maturation of transfer RNA (tRNA) involves extensive chemical modification of the constituent nucleosides and results in the introduction of significant chemical diversity to tRNA. Many of the pathways to these modified nucleosides are characterized by chemically complex transformations, some of which are unprecedented in other areas of biology. To illustrate the scope of the field, recent progress in understanding the enzymology leading to the formation of two distinct classes of modified nucleosides, the thiouridines and queuosine, a 7-deazaguanosine, is reviewed. In particular, recent data validating the involvement of several proposed intermediates in the formation of thiouridines are discussed, including …