Physical Sciences and Mathematics Commons^™

Analysis Of Botulinum Toxin A And Interacting Proteins In Skeletal Muscle Cells: An Investigation Into The Mechanisms Behind Botulinum Toxin A As A Treatment For Chronic Exertional Compartment Syndrome, Lauren Kee

Honors Program Projects

Background: Chronic exertional compartment syndrome (CECS) is a condition in which muscle tissue expands against the surrounding fascia during activity and is compressed along with the nerves and blood vessels within the muscle compartment, leading to abnormally high intracompartmental pressure (ICP) and debilitating pain. Treatment typically includes fasciotomy, which results in significant levels of CECS recurrence; however, botulinum toxin A (BoNT-A) injection has recently been seen to decrease both ICP and pain through an unknown mechanism with little to no recurrence.

Methods: In this study, cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), prostaglandin E₂ receptor 4 (EP4), endothelial nitric oxide synthase (eNOS), …

Stand Location Variance As An Indicator Of Disturbance Regime In A Monotypic Tsuga Canadensis Forest, Cole J. Doolittle

Honors Program Projects

Disturbance regimes, which are critical components of forest ecosystems, influence forest morphology, biodiversity, and regeneration. The heterogeneity of disturbance regimes are not well understood on small scales. In this study I analyzed tree cores from five sites within a Tsuga canadensis (Eastern hemlock) forest in northern Wisconsin to investigate disturbance regimes through mean growth release criteria. This study investigated the following questions: 1) Are disturbance regimes in T. canadensis stand level or site specific? 2) If disturbances are site specific, is site location an indicator of disturbance regime? 3) Do site characteristics such as density and tree diameter at breast …

Countercurrent Chromatography Fractions Of Plant Extracts With Anti-Tuberculosis Activity, Douglas Armstrong, Nathan C. Krause, Drew Frey, J. Brent Friesen, Baojie Wan, Jordan Gunn, Scott Franzblau

Faculty Scholarship – Chemistry

Samples of numerous plant species were received from the southwestern part of the USA, from Richard Spjut, and plant samples were collected here in Illinois. All were extracted with typical solvents, giving crude residues, some of which were subjected to chromatographic methods. Some of the crude residues and some of the fractions were tested for anti-tuberculosis activity and/or antibacterial activity.

In a general way, bioactive natural products are dealt with very well by Liang & Fang. More specifically, the southwestern part of the United States has a large variety of indigenous plants many of which have not been investigated for …

Anti-Tb And Antibacterial Activities Of Natural Products Extracts, Douglas Armstrong, Nathan Krause, Drew Frey

Faculty Scholarship – Chemistry

Samples of numerous plant species were received from the southwestern part of the USA from Richard Spjut, and plant samples were collected here in Illinois. All were extracted with typical solvents, giving crude residues, some of which were subjected to counter-current or flash chromatographic methods. Some of the crude extracts and chromatographic fractions had anti-tuberculosis and/or antibacterial activity.

In a general way, bioactive natural products are dealt with very well by Liang & Fang, 2006. More specifically, the southwestern part of the United States has a large variety of indigenous plants, many of which have not been investigated for their …

Scholar Week, James Upchurch

Scholar Week Archives (2011-2015)

ONU's Scholar Week #5.

Ranking Trails Based On Natural Hazards Instead Of Difficulty: A Case Study On Starved Rock State Park, Julia Ryherd

Honors Program Projects

Starved Rock State Park in North-Central Illinois is not topographically flat as are many glaciated areas of Illinois. Its deep canyons and steep valley walls provide the backdrop for a diverse variety of natural hazards. Geologic hazards include steep canyon walls, flooding with erosion events, high elevation vantage points, and rock falls. Other natural hazards include falling tree branches and steep staircases. ArcGIS was used to record locations of both hazards and injuries along the trails and feature classes were made for each hazard. These feature classes were spatially joined and a weighted sum computed to create a hazard rating …

Scholar Week, Janna Mclean

Scholar Week Archives (2011-2015)

ONU's Scholar Week #4.

Relationships Between Elements Of Leslie Matrices And Future Growth Of The Population, Lorisha Lynn Riley

Honors Program Projects

Leslie matrices have been used for years to model and predict the growth of animal populations. Recently, general rules have been applied that can relatively easily determine whether an animal population will grow or decline. My mentor, Dr. Justin Brown and I examine, more specifically, whether there are relationships between certain elements of a population and the dominant eigenvalue, which determines growth. Not only do we consider the general 3x3 Leslie matrix, but also we looked into modified versions for incomplete data and migration models of Leslie matrices. We successfully found several connections within these cases; however, there is much …

Scholar Week, Gregg A. Chenoweth

Scholar Week Archives (2011-2015)

ONU's Scholar Week flyer #3.

Scholar Week, Gregg A. Chenoweth

Scholar Week Archives (2011-2015)

ONU Scholar Week #2.

Scholar Week, Gregg Chenoweth

Scholar Week Archives (2011-2015)

During Scholar Week we take inspiration from 18th century preacher-scholar |ohn Wesley. As “a denominational university in the Wesleyan tradition,” scholarship and piety are thoroughly compatible here. So, in Scholar Week we tune our ear to the gong and echo of Wesley. It is not just history, but his story, even to this day. In our own scholarship projects we join a great cloud of Christians not educated out of their faith, but fashioning an educated faith, where the love of the Lord by heart, soul, strength, and mind is our great and worthy cause.

The Chainsaw And The White Oak: From Astrobiology To Environmental Sustainability, Leo R. Finkenbinder, Dwight E. Neuenschwander

Faculty Scholarship – Biology

An American biology professor befriends a Costa Rican farmer who through their relationship stops farming and forest clearing to establish a tourist and research center devoted to saving the country's cloud forest. The Chacon family's experience provides a studied model of sustainability, known in environmental circles as the "White Oak Model."