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Full-Text Articles in Physical Sciences and Mathematics
Polya Db3: A Database Cataloging Polyadenation Sites(Pas) Across Different Species And Their Conservation, Ram Mohan Nambiar
Polya Db3: A Database Cataloging Polyadenation Sites(Pas) Across Different Species And Their Conservation, Ram Mohan Nambiar
Theses
Polyadenation is an important process occurring in the messenger RNA that involves cleavage of 3 end nascent mRNAs and addition of poly(A) tails. For this thesis,I present PolyA DB3 ,a database cataloging cleavage and polyadenylation sites (PASs) in several genomes specifically for human,mouse,rat and chicken. This database is based on deep sequencing data. PASs are mapped by the 3’ region extraction and deep sequencing (3’READS) method, ensuring unequivocal PAS identification. Large volume of data based on diverse biological samples is used to increase PAS coverage and provide PAS usage information. Strand-specific RNA-seq data were used to extend annotated 3’ ends …
Hypoxic And Viral Contributions To The Etiopathogenesis Of Schizophrenia: A Whole Transcriptome Analysis, Kathryn A. Gorski
Hypoxic And Viral Contributions To The Etiopathogenesis Of Schizophrenia: A Whole Transcriptome Analysis, Kathryn A. Gorski
Theses
Schizophrenia is a mental illness with a complex and as of yet unclear etiology. It is highly heritable and has a strong polygenic character, however, studies examining the genetics of schizophrenia have not sufficiently explained all variability in its prevalence. Environmental causes are theorized to have a non trivial contribution to the pathoetiology of schizophrenia, including interactions with genetic components, but these mechanisms remain unclear. Analyzing schizophrenia dysfunction using transcriptomic approaches is a paradigm still in its infancy, and fewer studies still have examined non neurological contributions to schizophrenia pathology with next generation sequencing technologies. This pilot study uses several …