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Articles 1 - 7 of 7
Full-Text Articles in Physical Sciences and Mathematics
2-D Electrophoresis Modeling Of Multienzyme Cutting Of Polypeptides, Howard Mayes
2-D Electrophoresis Modeling Of Multienzyme Cutting Of Polypeptides, Howard Mayes
Theses
2-Dimensional Electrophoresis is one of the tools in the identification of proteins by molecular weight and pH. The display of molecular weight allows the researcher to quickly identify whether a specific protein or peptide string is in the sample. The pH measurement allows even better resolution between different species in the sample. The MultiEnzyme ElectroPhoresis (MEEP) program tries to model that by providing a graph that displays separated protein strings by both molecular weight and pH. The ability to cleave the protein with 43 different enzyme variations allows the researcher to analyze appropriate enzymes to isolate a protein subsequence before …
Vertical And Cross-Shore Distributions Of Barnacle Larvae In La Jolla, Ca Nearshore Waters: Implications For Larval Transport Processes, Malloree Lynn Hagerty
Vertical And Cross-Shore Distributions Of Barnacle Larvae In La Jolla, Ca Nearshore Waters: Implications For Larval Transport Processes, Malloree Lynn Hagerty
Theses
Many marine organisms begin their lives as tiny larvae that are at the mercy of ocean currents. Understanding the transport and subsequent dispersal of larvae is crucial, as it drives population connectivity in the ocean. Larval transport is a complex process involving both physical motions of the water and larval behavior. Vertical positioning is especially important because currents vary throughout the water column, and larvae at different depths will be advected differently. With swimming speeds insufficient to swim against currents, marine larvae can mediate cross-shore transport by controlling their depth distributions. Thus, the overall objective of this study was to …
Rational Drug Design Directed At Blocking The Initial Signaling Events In Lipopolysaccharide-Induced Sepsis., Christopher A. Tipton
Rational Drug Design Directed At Blocking The Initial Signaling Events In Lipopolysaccharide-Induced Sepsis., Christopher A. Tipton
Theses
Systemic Inflammatory Response Syndrome (SIRS) is classified as an immune system response to an infectious state. If left untreated, SIRS leads to sepsis, septic shock, end-organ dysfunction, and death. As a patient progresses through these stages, associations of acute respiratory distress, disseminated intravascular coagulation, and acute renal failure persist, resulting in millions of deaths annually. Lipopolysaccharide (LPS), a bacterial endotoxin, is released into the blood stream, triggering SIRS. LPS is found in the outer cell-wall of Gram-negative bacteria and is responsible for initiation of a devastating cytokine storm. One of the regions of LPS, lipid A, is a polyacylated glucosamine …
Larval Rockfish Diversity Abundance Dynamics In Association With A Marine Protected Area In The Southern California Bight, Dustin Chen
Theses
Marine protected areas (MPAs) are areas aimed at protecting natural and cultural resources that are often proposed as a way to alleviate the effects of overfishing on populations of targeted species; these areas have varying degrees of fishing and recreational use restrictions. In order to assess MPA efficacy, it is important to determine the mechanisms by which the presence of MPAs affect reproductive output within and potentially even beyond their boundaries. I attempted to address this through studying the responses of rockfish (Sebastes spp.) larval abundances to the presence of the Cowcod Conservation Areas (CCAs) located within the Southern California …
Network Exploration Of Correlated Multivariate Protein Data For Alzheimer's Disease Association, Matthew J. Lane
Network Exploration Of Correlated Multivariate Protein Data For Alzheimer's Disease Association, Matthew J. Lane
Theses
Alzheimer Disease (AD) is difficult to diagnose by using genetic testing or other traditional methods. Unlike diseases with simple genetic risk components, there exists no single marker determining as to whether someone will develop AD. Furthermore, AD is highly heterogeneous and different subgroups of individuals develop the disease due to differing factors. Traditional diagnostic methods using perceivable cognitive deficiencies are often too little too late due to the brain having suffered damage from decades of disease progression. In order to observe AD at early stages prior to the observation of cognitive deficiencies, biomarkers with greater accuracy are required. By using …
Novel Neuroevolution Techniques For The Life Science Domain, Timothy Manning
Novel Neuroevolution Techniques For The Life Science Domain, Timothy Manning
Theses
The life science domain is a high value research area, both in terms of the benefits in increased knowledge and in societal impact. Much of the research funding has focused on wet lab based approaches to increase visibility into biological processes and producing maximal relevant information on which to make decisions. Given the complexity of biological functions, in many cases this has led to an information overload. Researchers are now able to routinely generate and access petabytes of data as a result of high throughput experiments, and this capability is growing. This data can be difficult to interpret and intractable …
An Application Of Time Series Methods To Investigate Eu Dairy Commodity Price Dynamics, Dennis Bergmann
An Application Of Time Series Methods To Investigate Eu Dairy Commodity Price Dynamics, Dennis Bergmann
Theses
Fundamental changes to the common agricultural policy (CAP) have led to greater market orientation which in turn has resulted in significantly changed price dynamics of EU dairy prices. These changed dynamics include sharply increased price variability of EU farm gate milk prices as well EU dairy commodity prices such as butter and Skimmed Milk Powder (SMP). In addition it was expected that EU dairy prices will align to Word dairy prices. This alignment of prices would also see an alignment of volatility levels which were significantly higher for World dairy prices than EU dairy prices. The aim of this thesis …