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Full-Text Articles in Physical Sciences and Mathematics
Ndp Kinase Moves Into Developing Primary Cilia, Kimberly A. P. Mitchell, Betty C. Gallagher, Gabor Szabo, Angela De S. Otero
Ndp Kinase Moves Into Developing Primary Cilia, Kimberly A. P. Mitchell, Betty C. Gallagher, Gabor Szabo, Angela De S. Otero
Faculty Publications and Presentations
Inmunofluorescence staining of murine NIH3T3 fibroblasts grown at high density shows that conventional nucleoside diphosphate (NDP) kinases A and B localize to a sensory organelle, the primary cilium. Similar results are obtained with Xenopus A6 kidney epithelial cells, suggesting that NDP kinases are a universal component of the primary cilium. The translocation of NDP kinase into primary cilia depends on size, taking place only when cilia reach a critical length of 5-6 μm. In mature cilia, NDP kinases are distributed along the ciliary shaft in a punctate pattern that is distinct from the continuous staining observed with acetylated α-tubulin, a …