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- Bacteria (2)
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- Energy transfer (2)
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- Ammonium perchlorate (1)
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- Gait recognition (1)
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Articles 1 - 17 of 17
Full-Text Articles in Physical Sciences and Mathematics
Development Of A Methodology For The Quantification Of Reaerosolization Of A Biological Contaminant Surrogate Particle From Military Uniform Fabric, George D. Cooksey
Development Of A Methodology For The Quantification Of Reaerosolization Of A Biological Contaminant Surrogate Particle From Military Uniform Fabric, George D. Cooksey
Theses and Dissertations
During a mass casualty medical evacuation after a bioaerosol attack, a decontamination method is needed that is effective at both decontamination and preventing the secondary hazard of biological particles reaerosolizing from contaminated clothing. However, neither the efficacy of current decontamination methods nor the risk of biological particle reaerosolization is significantly explored in existing literature. The goals of this thesis were to develop a repeatable methodology to quantify the reaerosolization of a biological contaminate off Airman Battle Uniform (ABU) fabric swatches, and to test the efficacy of one decontamination method (high-volume, low-pressure water) using 1 mpolystyrene latex (PSL) spheres as a …
Characterization Of Silicon Ion Exposure On Deinococcus Radiodurans, Richard F. Daughtry
Characterization Of Silicon Ion Exposure On Deinococcus Radiodurans, Richard F. Daughtry
Theses and Dissertations
Deinococcus radiodurans is a robust bacterium that is known for its extraordinary resistance to ionizing radiation. In general, many of the investigations of this bacterium's resistance have revolved around low linear energy transfer radiation, such as gamma and electron radiation. This study explored Deinococcus radiodurans's ability to survive high linear energy transfer radiation, specifically proton and neutron radiation. Deinococcus radiodurans was dehydrated to reduce the effects of low linear energy transfer radiation. The bacteria were exposed to both neutron and proton radiation of varying amounts and rehydrated. The resulting colonies were counted and compared to colonies of non-irradiated control samples …
Characterization Of The Effects Of Heavy Charged Particle Exposure On The Radiation Resistant Bacterium Deinococcus Radiodurans, Todd A. Bryant
Characterization Of The Effects Of Heavy Charged Particle Exposure On The Radiation Resistant Bacterium Deinococcus Radiodurans, Todd A. Bryant
Theses and Dissertations
Although not an extremophile, Deinococcus radiodurans has proven to have exceptional resistance to ionizing radiation, specifically via gamma and X-ray photons. To date, no known experiments have bombarded the bacterium with charged particles larger than hydrogen. This study explored the effects on the organism’s ability to survive high linear energy transfer heavy-charged particle exposures of oxygen ions. It also investigated the effects of low linear energy transfer ultraviolet radiation on various mutants. Two uvrB mutants were created to ascertain the importance of the gene in single-strand break repair following gamma irradiation and two recF mutants were created to explore the …
Modeling Radiation Effectiveness For Inactivation Of Bacillus Spores, Emily A. Knight
Modeling Radiation Effectiveness For Inactivation Of Bacillus Spores, Emily A. Knight
Theses and Dissertations
This research models and analyzes the inactivation of Bacillus spores following a radiation exposure and the process enacted by the Bacillus spore to repair the resulting damage. Irradiation of a spore and the medium surrounding the spore induces chemical reactions that produce reactive oxygen species (ROS). This research will consider the reaction- diffusion of these ROS throughout the spore. These ROS can react with the spore's DNA and enzymes to degrade them to such an extent that the DNA cannot be repaired or replicated, thus causing spore death. In order to survive a dose of radiation, a spore must repair …
In Vitro Toxicity Of Silver Nanoparticles In Human Lung Epithelial Cells, Christina R. Kearns
In Vitro Toxicity Of Silver Nanoparticles In Human Lung Epithelial Cells, Christina R. Kearns
Theses and Dissertations
Nanotechnology is quickly becoming incorporated into everyday products and uses. Silver nanoparticles, specifically, are being used in commercial products, to include aerosols. The purpose of this research was to determine whether silver nanoparticles are toxic to human lung epithelial cells. Different types (coated vs. uncoated), concentrations (10, 50, 100, and 200 µg/mL) and sizes (coated 5 and 80nm, uncoated 10 and 80nm) of silver nanoparticles were used during this study. Toxicity measurements were completed through in vitro techniques. Another study was also completed on toxicity mechanisms by measuring the reactive oxygen species (ROS) generated. Results showed that silver nanoparticles induce …
Statistical Approach To The Characterization And Recognition Of Human Gaits, Derrick M. Chelliah
Statistical Approach To The Characterization And Recognition Of Human Gaits, Derrick M. Chelliah
Theses and Dissertations
This thesis addresses the final portion of a complete process for human gait recognition. The thesis takes as input information that has been generated from videotaping walking individuals and converting their gaits into numerical data that measures the locations of various points on the body through time. Beginning with this data, this thesis uses a variety of mathematical and statistical methods to create identifying signatures for each individual and identify them on the basis of that signature. The end goal is to achieve under controlled laboratory conditions human gait recognition, an identification method which does not require contact or cooperation …
Statistical Approach To Background Subtraction For Production Of High-Quality Silhouettes For Human Gait Recognition, Jennifer J. Samler
Statistical Approach To Background Subtraction For Production Of High-Quality Silhouettes For Human Gait Recognition, Jennifer J. Samler
Theses and Dissertations
This thesis uses a background subtraction to produce high-quality silhouettes for use in human identification by human gait recognition, an identification method which does not require contact with an individual and which can be done from a distance. A statistical method which reduces the noise level is employed resulting in cleaner silhouettes which facilitate identification. The thesis starts with gathering video data of individuals walking normally across a background scene. From there the video is converted into a sequence of images that are stored as joint photographic experts group (jpeg) files. The background is subtracted from each image using a …
Analysis Of Bacterial Population And Distribution In The Developing Strata Of A Constructed Wetland Used For Chlorinated Ethene Bioremediation, Milton J. Clausen Jr.
Analysis Of Bacterial Population And Distribution In The Developing Strata Of A Constructed Wetland Used For Chlorinated Ethene Bioremediation, Milton J. Clausen Jr.
Theses and Dissertations
Chlorinated hydrocarbons and their degradation products are among of the most common organic groundwater contaminates in the United States. These compounds attack the central nervous system in animals and can affect the photosynthesis of plants. These compounds are also resistant to degradation in the environment and, because of this, pose a risk to any ecosystem in which they are present. This study identified the dominant microbial species in a constructed treatment wetland at Wright-Patterson AFB, Dayton, Ohio using 16S rRNA gene sequence analysis. Samples were taken from three different depths and during each of the four seasons. These samples were …
Stochastic Intra-Cellular Modeling, Thomas E. Hopkins
Stochastic Intra-Cellular Modeling, Thomas E. Hopkins
Theses and Dissertations
Air Force personnel may sometimes come into contact with potentially harmful chemicals while performing their duties. Of course the Air Force desires to keep any potential health risks to its members to a minimum. To this end the Air Force would like to identify which chemicals are toxic, their level of toxicity, and the processes by which these chemicals disrupt normal biological activities at the cellular level. The development of mathematical models can be of great benefit to toxicity studies. Because real world systems involve randomness, that is noise, and the desire is to create mathematical models to represent those …
Deterministic Intracellular Modeling, Jacqueline B. Young
Deterministic Intracellular Modeling, Jacqueline B. Young
Theses and Dissertations
The United States Air Force is interested in the potential side effects at the cellular level from exposure to mission-essential chemicals. Presently, Air Force toxicology studies are conducted to help shed light in identifying potential hazards to workers. However, it takes a considerable amount of money, resources, and time to obtain and analyze experimental results from toxicology studies. The necessity for innovative methods that enable researchers to more effectively generate and analyze data is apparent.
A System Dynamics Investigation Of Genetic Drift And Translocation In The Red-Cockaded Woodpecker Metapopulation, Jason E. Yates
A System Dynamics Investigation Of Genetic Drift And Translocation In The Red-Cockaded Woodpecker Metapopulation, Jason E. Yates
Theses and Dissertations
The red-cockaded woodpecker (Picoides borealis) is classified under the Endangered Species Act of 1973 as an endangered species As such, the red-cockaded woodpecker (RCW) is afforded strict protection in an effort to return the RCW population to a self-sustainable level. Endemic to southeastern United States mature pine forests, the presence of the RCW impacts the operations of many Department of Defense (DoD) installations. A particular challenge in sustaining what are often small populations of RCW at these locations is the loss of genetic variation due to genetic drift. The optimal method for mitigating such loss is through the artificial immigration, …
Comparing Clustering Algorithms For Use With Genomic And Proteomic Data, Rebecca A. Olson
Comparing Clustering Algorithms For Use With Genomic And Proteomic Data, Rebecca A. Olson
Theses and Dissertations
The Human Genome Project and related projects have resulted in the development of a number of new experimental and analytic tools for use in genomic and proteomic research. In the area of toxicogenomics, researchers are concerned with how genes react to exposure to certain chemicals. The United States Air Force is interested in the effect of exposure to mission-essential chemicals. Although military personnel may come into contact with chemicals such as hydrazine, risk assessment is usually very limited. On the genomic level, risk assessment is a multi-stop and multi-disciplinary process. The process begins with an experiment that exposes cells to …
Effects On The Red-Cockaded Woodpecker From Various Spatial And Temporal Applications Of Management Practices, Chad F. Schroeder
Effects On The Red-Cockaded Woodpecker From Various Spatial And Temporal Applications Of Management Practices, Chad F. Schroeder
Theses and Dissertations
The Red-Cockaded Woodpecker (RCW) is an endangered species endemic to southeastern pine forests in the United States. RCWs are cooperative breeding birds that live together in clusters of old-growth pine trees in which they construct their nesting cavities. The cavities are constructed in living pines, which are predominantly longleaf pines. RCWs also forage upon older pines, preferably longleaf pine. The Endangered Species Act, along with other DoD regulations, requires DoD installations to protect the RCWs and restore their habitat. A popular management practice converts off-site (non-native) pines back to a region's indigenous pines. Conversion provides the best long term RCW …
Chromate Dissociation From Primer Paint In Simulated Lung Fluid, Tiffany J. R. Morgan
Chromate Dissociation From Primer Paint In Simulated Lung Fluid, Tiffany J. R. Morgan
Theses and Dissertations
OSHA has proposed a new strontium chromate exposure standard that would potentially cause Air Force paint facilities to be in violation of the proposed standard if adopted. This proposed reduction make the continued use of chromate containing primer paints very difficult. There is currently no acceptable replacements for chromate containing primer paints on AF aircraft. This study suggests that paint particles with chromate bound in primer paint may be unavailable for bodily absorption if inhaled and a reduced standard for painting applications may be unnecessary. Primer paint overspray was collected into simulated lung fluid (SLF) and allowed 6 hr, 24 …
Modeling Chemical Absorption Through Membranes, Jeffrey M. Hemmes
Modeling Chemical Absorption Through Membranes, Jeffrey M. Hemmes
Theses and Dissertations
Understanding the processes involved in dermal penetration of chemicals and drugs is important to both toxicologists and pharmacologists. Researchers developing new drugs are interested in enhancing the penetration of chemicals through the skin, while environmental professionals are interested in limiting such penetration. For both types of applications, predictive biologically-based mathematical models can be very useful in understanding the processes involved, particularly when such models are based on physiological and biochemical parameters which can be measured experimentally. In this thesis we study two existing physiologically-based pharmacokinetic (PBPK) models that predict concentrations of neat and aqueous dibromomethane (DBM) absorbed into and through …
Effects Of Ammonium Perchlorate On The Thyroid Hormone Levels Of The Sprague-Dawley Rat, James H. King Jr.
Effects Of Ammonium Perchlorate On The Thyroid Hormone Levels Of The Sprague-Dawley Rat, James H. King Jr.
Theses and Dissertations
The purpose of this research was to determine the threshold dose for ammonium perchlorate (AP) in the Sprague-Dawley rat. No dose response data exist for AP and the EPA has studied literature on the subject of perchlorates to determine a provisional reference dose. The Perchiorate Group, a consortium of DoD and industry representatives, believes this provisional reference dose is too conservative. This experiment was executed to provide dose response data on which to base a more accurate reference dose. The study consisted of eight groups of 12 Sprague-Dawley rats, six male and six female, which were exposed to incremental doses …
Physiologically-Based Pharmacokinetic Modeling Of Skin Absorption Using Dermal Subcompartments, Richard L. Bookout Jr.
Physiologically-Based Pharmacokinetic Modeling Of Skin Absorption Using Dermal Subcompartments, Richard L. Bookout Jr.
Theses and Dissertations
Dermal penetration of chemicals and drugs is important to both toxicologists and pharmacologists. Drug developers try to enhance and environmental professionals try to limit penetration of chemicals through the skin. Both can use predictive biologically-based mathematical models to assist in understanding the processes involved. When these models are based on physiological and biochemical parameters which can be measured in the laboratory, they can be extremely useful. Appropriately validated models based on first principles can be predictive of human exposures when the processes involved are adequately understood. In this thesis we develop four new physiologically-based pharmacokinetic (PBPK) models to predict blood …