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Full-Text Articles in Physical Sciences and Mathematics
Application Of The Tissue Residue Approach In Ecological Risk Assessment, Steven P. Bradbury, Keith G. Sappington, Todd S. Bridges, Russell J. Erickson, A. Jan Hendriks, Roman P. Lanno, James P. Meador, David R. Mount, Mike H. Salazar, Doug J. Spry
Application Of The Tissue Residue Approach In Ecological Risk Assessment, Steven P. Bradbury, Keith G. Sappington, Todd S. Bridges, Russell J. Erickson, A. Jan Hendriks, Roman P. Lanno, James P. Meador, David R. Mount, Mike H. Salazar, Doug J. Spry
Steven P. Bradbury
The objective of this work is to present a critical review of the application of the tissue residue approach (TRA) in ecological risk and/or impact assessment (ERA) of chemical stressors and environmental criteria development. A secondary goal is to develop a framework for integrating the TRA into ecological assessments along with traditional, exposure concentration-based assessment approaches. Although widely recognized for its toxicological appeal, the utility of the TRA in specific applications will depend on numerous factors, such as chemical properties, exposure characteristics, assessment type, availability of tissue residue-response data, and ability to quantify chemical exposure. Therefore, the decision to use …
Crucial Role Of Mechanisms And Modes Of Toxic Action For Understanding Tissue Residue Toxicity And Internal Effect Concentrations Of Organic Chemicals, Beate I. Escher, Roman Ashauer, Scott Dyer, Joop L. M. Hermens, Jong-Hyeon Lee, Heather A. Leslie, Philipp Mayer, James P. Meador, Michael S. J. Warne
Crucial Role Of Mechanisms And Modes Of Toxic Action For Understanding Tissue Residue Toxicity And Internal Effect Concentrations Of Organic Chemicals, Beate I. Escher, Roman Ashauer, Scott Dyer, Joop L. M. Hermens, Jong-Hyeon Lee, Heather A. Leslie, Philipp Mayer, James P. Meador, Michael S. J. Warne
United States Department of Commerce: Staff Publications
This article reviews the mechanistic basis of the tissue residue approach for toxicity assessment (TRA). The tissue residue approach implies that whole-body or organ concentrations (residues) are a better dose metric for describing toxicity to aquatic organisms than is the aqueous concentration typically used in the external medium. Although the benefit of internal concentrations as dose metrics in ecotoxicology has long been recognized, the application of the tissue residue approach remains limited. The main factor responsible for this is the difficulty of measuring internal concentrations. We propose that environmental toxicology can advance if mechanistic considerations are implemented and toxicokinetics and …