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Full-Text Articles in Physical Sciences and Mathematics
Per- And Polyfluoroalkyl Substances And Calcifications Of The Coronary And Aortic Arteries In Adults With Prediabetes: Results From The Diabetes Prevention Program Outcomes Study, Citlalli Osorio-Yáñez, Marco Sanchez-Guerra, Andres Cardenas, Pi-I D. Lin, Russ Hauser, Diane R. Gold, Ken P. Kleinman, Marie-France Hivert, Abby F. Fleisch, Antonia M. Calafat
Per- And Polyfluoroalkyl Substances And Calcifications Of The Coronary And Aortic Arteries In Adults With Prediabetes: Results From The Diabetes Prevention Program Outcomes Study, Citlalli Osorio-Yáñez, Marco Sanchez-Guerra, Andres Cardenas, Pi-I D. Lin, Russ Hauser, Diane R. Gold, Ken P. Kleinman, Marie-France Hivert, Abby F. Fleisch, Antonia M. Calafat
Biostatistics and Epidemiology Faculty Publications Series
Background: Per-and polyfluoroalkyl substances (PFAS) are endocrine disrupting chemicals that have been associated with cardiovascular risk factors including elevated body weight and hypercholesterolemia. Therefore, PFAS may contribute to the development of atherosclerosis and cardiovascular disease (CVD). However, no previous study has evaluated associations between PFAS exposure and arterial calcification. Methods and results: This study used data from 666 prediabetic adults enrolled in the Diabetes Prevention Program trial who had six PFAS quantified in plasma at baseline and two years after randomization, as well as measurements of coronary artery calcium (CAC) and ascending (AsAC) and descending (DAC) thoracic aortic calcification 13-14 …