Physical Sciences and Mathematics Commons^™

Predictive Power Of Wastewater For Nowcasting Infectious Disease Transmission: A Retrospective Case Study Of Five Sewershed Areas In Louisville, Kentucky, Fayette Klaassen, Rochelle H. Holm, Ted Smith, Ted Cohen, Aruni Bhatnagar, Nicolas A. Menzies

Faculty Scholarship

Background: Epidemiological nowcasting traditionally relies on count surveillance data. The availability and quality of such count data may vary over time, limiting representation of true infections. Wastewater data correlates with traditional surveillance data and may provide additional value for nowcasting disease trends. Methods: We obtained SARS-CoV-2 case, death, wastewater, and serosurvey data for Jefferson County, Kentucky (USA), between August 2020 and March 2021, and parameterized an existing nowcasting model using combinations of these data. We assessed the predictive performance and variability at the sewershed level and compared the effects of adding or replacing wastewater data to case and death reports. …

Microbial Community Function And Bacterial Pathogen Composition In Pit Latrines In Peri-Urban Malaw, Savanna K. Smith, Benjamin B. Risk, Rochelle H. Holm, Elizabeth Tilley, Petros Chigwechokha, Drew Capone, Joe Brown, Francis L. De Los Reyes Iii

Faculty Scholarship

Despite the widespread global reliance on pit latrines as improved sanitation systems, the decomposition of waste within pit latrines is poorly understood. One area needing elucidation is the characterization and function of microbial communities within pit latrines. To address this gap, we characterized the microbial communities of 55 lined pit latrines at three sampling layers from two communities in peri-urban Malawi. The microbial communities of the fecal sludge samples were analyzed for beta diversity, pathogen presence, and functional profiling. Household surveys were conducted and used to compare microbial community patterns to household characteristics and pit latrine use patterns. Compared to …

Addressing The Challenges Of Establishing Quality Wastewater Or Non- Sewered Sanitation-Based Surveillance, Including Laboratory And Epidemiological Considerations, In Malawi, Rochelle H. Holm, Ruth Nyirenda, Ted Smith, Petros Chigwechokha

Faculty Scholarship

Learning from clinical laboratories, wastewater or environmental (including non-sewered sanitation) environmental microbiology laboratories can be established in resource-limited settings that focus on pathogen detection and pandemic prevention. Transparent discussions on the laboratory challenges and adaptations required for this can help meet the future requirements of health research and surveillance. This report aims to describe the challenges encountered when setting up a wastewater or environmental laboratory for multipathogen surveillance in Malawi, a resource-limited setting, as well as the lessons learnt. We identified nine unifying themes: what to monitor, human resource capacity, indicators of data quality, equipment availability, supply of consumable goods, …

What’S Scope 3 Good For?, Madison Condon

Faculty Scholarship

Opposition to the Securities and Exchange Commission’s (“SEC”) new rule on updated climate risk reporting has focused on one category of disclosures as particularly objectionable: Scope 3 emissions.⁷ Otherwise known as “supply chain emissions,” Scope 3 emissions have been voluntarily reported by a growing number of companies since the term was invented as part of the Greenhouse Gas Protocol in 2001.⁸ They include all the emissions both up and downstream of a corporations’ own activities: the emissions of the privately-owned factory that produced the shoes Target sells, as well as the emissions you burn while driving to the …

Beyond Covid-19: Designing Inclusive Public Health Surveillance By Including Wastewater Monitoring, Rochelle H. Holm, Na'taki Osborne Jelks, Rebecca Schneider, Ted Smith

Faculty Scholarship

Wastewater-based epidemiology is a promising and expanding public health surveillance method. The current wastewater testing trajectory to monitor primarily at community wastewater treatment plants was necessitated by immediate needs of the pandemic. Going forward, specific consideration should be given to monitoring vulnerable and underserved communities to ensure inclusion and rapid response to public health threats. This is particularly important when clinical testing data are insufficient to characterize community virus levels and spread in specific locations. Now is a timely call to action for equitably protecting health in the United States, which can be guided with intentional and inclusive wastewater monitoring.

Online Dashboards For Sars-Cov-2 Wastewater Data Need Standard Best Practices: An Environmental Health Communication Agenda, Colleen C. Naughton, Rochelle H. Holm, Nancy J. Lin, Brooklyn P. James, Ted Smith

Faculty Scholarship

The COVID-19 pandemic has highlighted the benefits of wastewater surveillance to supplement clinical data. Numerous online information dashboards have been rapidly, and typically independently, developed to communicate environmental surveillance data to public health officials and the public. In this study, we review dashboards presenting SARS-CoV-2 wastewater data and propose a path toward harmonization and improved risk communication. A list of 127 dashboards representing 27 countries was compiled. The variability was high and encompassed aspects including the graphics used for data presentation (e.g., line/bar graphs, maps, and tables), log versus linear scale, and 96 separate ways of labeling SARS-CoV-2 wastewater concentrations. …

Climate Services: The Business Of Physical Risk, Madison Condon

Faculty Scholarship

A growing number of investors, insurers, financial services providers, and nonprofits rely on information about localized physical climate risks, like floods, hurricanes, and wildfires. The outcomes of these risk projections have significant consequences in the economy, including allocating investment capital, impacting housing prices and demographic shifts, and prioritizing adaptation infrastructure projects. The climate risk information available to individual citizens and municipalities, however, is limited and expensive to access. Further, many providers of climate services use black box models that make overseeing the scientific rigor of their methodologies impossible— a concern given scientific critiques that many may be obfuscating the uncertainty …

Generative Ai As A Tool For Environmental Health Research Translation, Lauren B. Anderson, Dhiraj Kanneganti, Mary Bentley Houk, Rochelle H. Holm, Ted Smith

Faculty Scholarship

One valuable application for generative artificial intelligence (AI) is summarizing research studies for non-academic readers. We submitted five articles to Chat Generative Pre-trained Transformer (ChatGPT) for summarization, and asked the article's author to rate the summaries. Higher ratings were assigned to more insight-oriented activities, such as the production of eighth-grade reading level summaries, and summaries highlighting the most important findings and real-world applications. The general summary request was rated lower. For the field of environmental health science, no-cost AI technology such as ChatGPT holds the promise to improve research translation, but it must continue to be improved (or improve itself) …

Environmental Health Justice Across The Globe, Arnita Gadson, Rochelle H. Holm

Faculty Scholarship

No abstract provided.

"Green" Corporate Governance, Madison Condon

Faculty Scholarship

This chapter explores the rise and future of “green” corporate governance, including how concerns about the changing climate are shaping long-extant debates in corporate law.² This area is difficult to survey in one short chapter, both because it has exploded in importance, and because it intersects in its own way with many of the topics discussed in the above chapters. Compliance, directors’ duties, corporate purpose, corporate groups, and investor stewardship, are just a few of the issues bound up in the rapid and recent shift toward thinking about climate change and its intersection with corporate governance.³

The rise …

Detection Of Human, Porcine And Canine Picornaviruses In Municipal Sewage Sludge Using Pan-Enterovirus Amplicon-Based Long-Read Illumina Sequencing, Temitope O. C. Faleye, Erin M. Driver, Devin A. Bowes, Rochelle H. Holm, Daymond Talley, Ray Yeager, Aruni Bhatnagar, Ted Smith, Arvind Varsani, Rolf U. Halden, Matthew Scotch

Faculty Scholarship

We describe the successful detection of human, porcine and canine picornaviruses (CanPV) in sewage sludge (at each stage of treatment) from Louisville, Kentucky, USA, using Pan-enterovirus amplicon-based long-read Illumina sequencing. Based on publicly available sequence data in GenBank, this is the first detection of CanPV in the USA and the first detection globally using wastewater-based epidemiology. Our findings also suggest there might be clusters of endemic porcine enterovirus (which have been shown capable of causing systemic infection in porcine) circulation in the USA that have not been sampled for around two decades. Our findings highlight the value of WBE coupled …

Estimating Sewage Flow Rate In Jefferson County, Kentucky, Using Machine Learning For Wastewater-Based Epidemiology Applications, Dhiraj Kanneganti, Lauren E. Reinersman, Rochelle H. Holm, Ted Smith

Faculty Scholarship

Direct measurement of the flow rate in sanitary sewer lines is not always feasible and is an important parameter for the normalization of data used in wastewater-based epidemiology applications. Machine learning to estimate past wastewater influent flow rates supporting public health applications has not been studied. The aim of this study was to assess wastewater treatment plant influent flow rates when compared with weather data and to retrospectively estimate flow rates in Louisville, Kentucky (USA), based on other data types using machine learning. A random forest model was trained using a range of variables, such as feces-related indicators, weather data …

Advancing The Use Of Fecal Sludge For Timelier And Better-Quality Epidemiological Data In Low- And Middle-Income Countries For Pandemic Prevention, Petros Chigwechokha, Renée Street, Rochelle H. Holm

Faculty Scholarship

No abstract provided.

The Detection Of Periodic Reemergence Events Of Sars-Cov-2 Delta Strain In Communities Dominated By Omicron, Claire E. Westcott, Kevin J. Sokoloski, Eric C. Rouchka, Julia H. Chariker, Rochelle H. Holm, Ray A. Yeager, Joseph B. Moore Iv, Erin M. Elliott, Daymond Talley, Aruni Bhatnagar

Faculty Scholarship

Despite entering an endemic phase, SARS-CoV-2 remains a significant burden to public health across the global community. Wastewater sampling has consistently proven utility to understanding SARS-CoV-2 prevalence trends and genetic variation as it represents a less biased assessment of the corresponding communities. Here, we report that ongoing monitoring of SARS-CoV-2 genetic variation in samples obtained from the wastewatersheds of the city of Louisville in Jefferson county Kentucky has revealed the periodic reemergence of the Delta strain in the presence of the presumed dominant Omicron strain. Unlike previous SARS-CoV-2 waves/emergence events, the Delta reemergence events were geographically restricted in the community …

Nationwide Public Perceptions Regarding The Acceptance Of Using Wastewater For Community Health Monitoring In The United States, A. Scott Lajoie, Asli Aslan, Rochelle H. Holm, Lauren B. Anderson, Heather D. Ness, Ted Smith

Faculty Scholarship

To assess the levels of infection across communities during the coronavirus disease 2019 pandemic, researchers have measured severe acute respiratory syndrome coronavirus 2 RNA in feces dissolved in sewer water. This activity is colloquially known as sewer monitoring and is referred to as wastewater-based epidemiology in academic settings. Although global ethical principles have been described, sewer monitoring is unregulated for health privacy protection when used for public health surveillance in the United States. This study used Qualtrics XM, a national research panel provider, to recruit participants to answer an online survey. Respondents (N = 3,083) answered questions about their knowledge, …

Quantifying The Relationship Between Sub-Population Wastewater Samples And Community-Wide Sars-Cov-2 Seroprevalence, Ted Smith, Rochelle H. Holm, Rachel J. Keith, Alok R. Amraotkar, Chance R. Alvarado, Krzysztof Banecki, Boseung Choi, Ian Santisteban, Adrienne M. Bushau-Sprinkle, Kathleen T. Kitterman, Joshua Fuqua, Krystal T. Hamorsky, Kenneth E. Palmer, J. Michael Brick, Aruni Bhatnagar, Grzegorz A. Rempala

Faculty Scholarship

Robust epidemiological models relating wastewater to community disease prevalence are lacking. Assessments of SARS-CoV-2 infection rates have relied primarily on convenience sampling, which does not provide reliable estimates of community disease prevalence due to inherent biases. This study conducted serial stratified randomized samplings to estimate the prevalence of SARS-CoV-2 antibodies in 3717 participants and obtained weekly samples of community wastewater for SARS-CoV-2 concentrations in Jefferson County, KY (USA) from August 2020 to February 2021. Using an expanded Susceptible-Infected-Recovered model, the longitudinal estimates of the disease prevalence were obtained and compared with the wastewater concentrations using regression analysis. The model analysis …

Educating Sanitation Professionals: Moving From Stem To Specialist Training In Higher Education In Malawi, Brighton A. Chunga, David Mkwambisi, Cassandra L. Workman, Francis L. De Los Reyes Iii, Rochelle H. Holm

Faculty Scholarship

Achieving the United Nations Sustainable Development Goals (SDGs) requires effective changes in multiple sectors including education, economics, and health. Malawi faces challenges in attaining the SDGs in general, and specifically in the sanitation sector. This paper aims to describe the existing landscape within public universities in Malawi to build a framework for training a cadre of locally trained experts. This is achieved by reviewing science, technology, engineering, and mathematics (STEM) degree programmes and assessing the extent of inclusion of sanitation education. The historical compartmentalization of academic programmes has resulted in few programmes to build on. Deliberate investment is needed to …

Sars-Cov-2 Rna Abundance In Wastewater As A Function Of Distinct Urban Sewershed Size, Rochelle H. Holm, Anish Mukherjee, Jayesh P. Rai, Ray A. Yeager, Daymond Talley, Shesh N. Rai, Aruni Bhatnagar, Ted Smith

Faculty Scholarship

During the COVID-19 pandemic, wastewater-based epidemiology has emerged as a promising approach for monitoring SARS-CoV-2 prevalence on a community-level. Despite much being known about the utility of making these measurements in large wastewater treatment plants, little is known about the correlation with finer geographic resolution, such as those obtained through sewershed sub-area catchments. This study aims to identify community wastewater surveillance characteristics between sewershed areas that affect the strength of the association of SARS-CoV-2 RNA detection in a metropolitan area. For this, wastewater from 17 sewershed areas were sampled in Louisville/Jefferson County, Kentucky (USA), from August 2020 to April 2021 …

Surveillance Of Rnase P, Pmmov, And Crassphage In Wastewater As Indicators Of Human Fecal Concentration Across Urban Sewer Neighborhoods, Kentucky, Rochelle H. Holm, M. Nagarkar, R. A. Yeager, D. Talley, A. C. Chaney, J. P. Rai, A. Mukherjee, S. N. Rai, A. Bhatnagar, Ted Smith

Faculty Scholarship

Wastewater surveillance has been widely used as a supplemental method to track the community infection levels of severe acute respiratory syndrome coronavirus 2. A gap exists in standardized reporting for fecal indicator concentrations, which can be used to calibrate the primary outcome concentrations from wastewater monitoring for use in epidemiological models. To address this, measurements of fecal indicator concentration among wastewater samples collected from sewers and treatment centers in four counties of Kentucky (N = 650) were examined. Results from the untransformed wastewater data over 4 months of sampling indicated that the fecal indicator concentration of human ribonuclease P (RNase …

Diversity Patterns Associated With Varying Dispersal Capabilities As A Function Of Spatial And Local Environmental Variables In Small Wetlands In Forested Ecosystems, Brett M. Tornwall, Amber L. Pitt, Bryan L. Brown, Joanna Hawley-Howard, Robert F. Baldwin

Faculty Scholarship

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. The diversity of species on a landscape is a function of the relative contribution of diversity at local sites and species turnover between sites. Diversity partitioning refers to the relative contributions of alpha (local) and beta (species turnover) diversity to gamma (regional/landscape) diversity and can be influenced by the relationship between dispersal capability as well as spatial and local environmental variables. Ecological theory predicts that variation in the distribution of organisms that are strong dispersers will be less influenced by spatial properties such as topography and connectivity of a region and …

Remaking Environmental Justice, Clifford Villa

Faculty Scholarship

From movements for civil rights in the 1960s and environmental protection in the 1970s, the environmental justice movement emerged in the 1980s and 1990s to highlight the disparate impacts of pollution, principally upon people of color and low-income communities. Over time, the scope of environmental justice expanded to address concerns for other dimensions of diversity. New and continuing challenges tell us that we need to reframe our understanding of environmental justice to ensure better protection for people going forward. One way to reframe this understanding may be to apply the heuristic of vulnerability analysis as proposed by legal theorist Martha …

Whose Lands? Which Public?: The Shape Of Public-Lands Law And Trump's National Monument Proclamations, Jedediah Britton-Purdy

Faculty Scholarship

President Trump issued a proclamation in December 2017 purporting to remove two million acres in southern Utah from national monument status, radically shrinking the Grand-Staircase Escalante National Monument and splitting the Bears Ears National Monument into two residual protected areas. Whether the President has the power to revise or revoke existing monuments under the Antiquities Act, which creates the national monument system, is a new question of law for a 112-year-old statute that has been used by Presidents from Theodore Roosevelt to Barack Obama to protect roughly fifteen million acres of federal land and hundreds of millions of marine acres. …

A Comparative Study Of Faecal Sludge Management In Malawi And Zambia: Status, Challenges And Opportunities In Pit Latrine Emptying, Rochelle H. Holm, James Madalitso Tembo, Bernard Thole

Faculty Scholarship

This review paper covers the issues of pit latrine emptying national policies and regulations with a focus on Malawi and Zambia. With 2.4 billion people worldwide still lacking improved sanitation facilities, developing countries need to look at policy, regulation and practice for household sanitation service provision with a new lens. What happens “next,” when improved sanitation facilities eventually become full? An emphasis on faecal sludge management has multiplied this important issue in the past few years. The authors compare the pit latrine emptying situation in Malawi and Zambia with a focus on status, challenges and opportunities. To build this comparison, …

Why Financial Lending Institutions Are Not Willing To Provide Services To The Private Sector For Rural Sanitation And Hygiene (Malawi)., Rochelle H. Holm, Victor Kasulo, Elijah Wanda

Faculty Scholarship

This study examines the gap between financial lending institutions and sanitation and hygiene services within Nkhata Bay District, Malawi. The study reviewed literature and policies, and conducted interviews, field observations, focus group discussions, household and lending institutions surveys, and peer reviewed workshops. Results suggest the following recommendations: promoting informal financial services, improving access for “risky” customers, improving knowledge for financial service providers, and promoting loan diversity. Although it has been found in Malawi households are willing to pay, cash, for improved sanitation, build-up of private sector businesses is hampered by lending institutions not willing to provide financial services.

Statistical Analysis Of Subsurface Diffusion Of Solar Energy With Implications For Urban Heat Stress, Mark P. Silverman

Faculty Scholarship

Analysis of hourly underground temperature measurements at a medium-size (by population) US city as a function of depth and extending over 5+ years revealed a positive trend exceeding the rate of regional and global warming by an order of magnitude. Measurements at depths greater than ~2 m are unaffected by daily fluctuations and sense only seasonal variability. A comparable trend also emerged from the surface temperature record of the largest US city (New York). Power spectral analysis of deep and shallow subsurface temperature records showed respectively two kinds of power-law behavior: 1) a quasi-continuum of power amplitudes indicative of Brownian …

Re-Storing The Earth: A Phenomenological Study Of Living Sustainably, Jessica B. Buckley

Faculty Scholarship

Living sustainably evokes ideas of lived, bodily engagement with and perception of the earth. Yet, modern ways of thinking and speaking have slowly alienated the earth from consciousness. Using phenomenological methods, the author examines the experience of living sustainably, exploring her own background and the idea of restoring the earth to consciousness, before examining the lives of two students dedicated to living sustainably. Components of upholding the earth, in-volving humanity, perceiving differences in studying and embodying sustainability, and engaging in choices fill the experience of living sustainably.

Grass Fires—An Unlikely Process To Explain The Magnetic Properties Of Prairie Soils, Stephani A. Roman, William C. Johnson, Christoph Geiss

Faculty Scholarship

It has been proposed that grass fires affect the magnetic properties of soils by combining generally reducing soil conditions with elevated temperatures. To explore this supposition, we analysed surface and subsurface samples from loessic soils and compared their differences in magnetic properties as a function of fire intensity. Fire intensity was established based on types of burnt vegetation, which ranged from low-intensity fires in short-grass areas to high-intensity fires in tall-grass and forested areas. We measured low-field magnetic susceptibility (χ), a common proxy for the abundance of magnetic minerals, frequency-dependent susceptibility (χ_FD), a proxy for …

China And Central Asia: A Significant New Energy Nexus, Fakhmiddin Fazilov, Xiangming Chen

Faculty Scholarship

China now accounts for almost 20 percent of the world’s energy consumption and its demand is still growing at high speed. In order to keep up with the expanding industry China turns to Central Asia with ambitious gas line projects and considers countries such as Kazakhstan, Turkmenistan and Uzbekistan to be key factors in its energy security nexus.

Sustainable Production Of Swine: Putting Lipstick On A Pig?, Michelle B. Nowlin

Faculty Scholarship

No abstract provided.

Investigation Of Visitors’ Participation And Willingness To Pay For The Baba Aman Recreational Park, Iran, M. Reza Ghanbarpour, Shima Sajjadi, S. Tahereh Hajiseyedjavadi, Xiangming Chen

Faculty Scholarship

The aim of this study is to estimate the recreational value of Baba Aman Natural Park near Bojnord in Northeast Iran. The recreational value of Baba Aman Park has been analyzed using a contingent valuation method. For this purpose, 201 on-site questionnaires were administered between June and September of 2006. Visitor’s willingness to pay (WTP) for Baba Aman recreational park has been estimated for future entrance fees associated with two scenarios including current conditions and proposed improvements of the recreational services in the park. Average WTP was estimated 1.5 and 2 times more than the current entrance fee, considering two …