Physical Sciences and Mathematics Commons^™

20,25-Diazacholesterol As An Oral Contraceptive For Black-Tailed Prairie Dog Population Management, Paul Nash, Carol A. Furcolow, Kimberly S. Bynum, Christi A. Yoder, Lowell A. Miller, John J. Johnston

Human–Wildlife Interactions

Black-tailed prairie dog (Cynomys ludovicianus) colonies can become overcrowded, and the colonies, landscape, and people affected by them may benefit from controlled populations. Contraception is a method that may be useful, particularly where lethal control is inappropriate or illegal. We investigated if oral administration of 20,25-diazacholesterol (DiazaCon®), an inhibitor of cholesterol and reproductive steroid hormone production, could reduce reproductive success of treated black-tailed prairie dogs in a fi eld trial. Ten treatments of approximately 45-mg DiazaCon per black-tailed prairie dog yielded a 47% reduction of young:adult ratios compared to control sites. Over a 3-month period, desmosterol, a cholesterol …