Physical Sciences and Mathematics Commons^™

Predicting Modes Of Toxic Action From Chemical Structure, Steven P. Bradbury, Christine L. Russom, Steven J. Broderius, Dean J. Hammermeister, Robert A. Drummond, Gilman D. Veith

Steven P. Bradbury

Like many of the papers in the Environmental Toxicology and Chemistry “Top 100” list, the development of the fathead minnow database [1] and the assignment of modes of action to the 617 chemicals therein resulted from a comprehensive research effort by a multidisciplinary team of researchers with expertise in quantitative structure–activity relationship (QSAR) modeling, chemistry, toxicokinetics, joint toxicity of chemical mixtures, and behavioral and aquatic toxicology. The fathead minnow database was the culmination of the US Environmental Protection Agency’s (USEPA) QSAR research program, which spanned nearly 20 yr, a rare program because many research planning efforts typically run within a …