Physical Sciences and Mathematics Commons^™

Dynamical Studies Of Model Membrane And Cellular Response To Nanosecond, High-Intensity Pulsed Electric Fields, Qin Hu

Electrical & Computer Engineering Theses & Dissertations

The dynamics of electroporation of biological cells subjected to nanosecond, high intensity pulses are studied based on a coupled scheme involving the current continuity and Smoluchowski equations. The improved pore formation energy model includes a dependence on pore population and density. It also allows for variable surface tension and incorporates the effects of finite conductivity on the electrostatic correction term, which was not considered by the simple energy models in the literature. It is shown that E(r) becomes self-adjusting with variations in its magnitude and profile. The whole scheme is self-consistent and dynamic.

An electromechanical analysis based on thin-shell theory …