Physical Sciences and Mathematics Commons^™

The Measure Of Efficiency And Effectiveness When Using Artificial Intelligence (Ai) In Radiology, Jordan Watts

Theses, Dissertations and Capstones

Introduction: The use of artificial intelligence in radiology has helped radiologists identify patterns and abnormalities in medical images to diagnose and treat patients. Deep learning and machine learning algorithms have been used to assist physicians in detecting features that are not noticeable to the human eye. The FDA has approved almost 400 AI algorithms for radiology and estimated that the market for AI in medical imaging would grow from $21.48 billion in 2018 to $264.85 billion in 2028.

Purpose of the Study: The purpose of this research was to evaluate the use of artificial intelligence in radiology to determine its …

Data-Centric Image Super-Resolution In Magnetic Resonance Imaging: Challenges And Opportunities, Mamata Shrestha

Graduate Theses and Dissertations

Super-resolution has emerged as a crucial research topic in the field of Magnetic Resonance Imaging (MRI) where it plays an important role in understanding and analysis of complex, qualitative, and quantitative characteristics of tissues at high resolutions. Deep learning techniques have been successful in achieving state-of-the-art results for super-resolution. These deep learning-based methods heavily rely on a substantial amount of data. Additionally, they require a pair of low-resolution and high-resolution images for supervised training which is often unavailable. Particularly in MRI super-resolution, it is often impossible to have low-resolution and high-resolution training image pairs. To overcome this, existing methods for …

3dgaunet: 3d Generative Adversarial Networks With A 3d U-Net Based Generator To Achieve The Accurate And Effective Synthesis Of Clinical Tumor Image Data For Pancreatic Cancer, Yu Shi, Hannah Tang, Michael J. Baine, Michael A. Hollingsworth, Huijing Du, Dandan Zheng, Chi Zhang, Hongfeng Yu

School of Computing: Faculty Publications

Pancreatic ductal adenocarcinoma (PDAC) presents a critical global health challenge, and early detection is crucial for improving the 5-year survival rate. Recent medical imaging and computational algorithm advances offer potential solutions for early diagnosis. Deep learning, particularly in the form of convolutional neural networks (CNNs), has demonstrated success in medical image analysis tasks, including classification and segmentation. However, the limited availability of clinical data for training purposes continues to represent a significant obstacle. Data augmentation, generative adversarial networks (GANs), and cross-validation are potential techniques to address this limitation and improve model performance, but effective solutions are still rare for 3D …

Expert Knowledge-Aware Image Difference Graph Representation Learning For Difference-Aware Medical Visual Question Answering, Xinyue Hu, Lin Gu, An Qiyuan, Mengliang Zhang, Liu Liangchen, Kobayashi Kazuma, Harada Tatsuya, M. Ronald Summers, Yingying Zhu

Computer Science and Engineering Faculty Publications

To contribute to automating the medical vision-language model, we propose a novel Chest-Xray Difference Visual Question Answering (VQA) task. Given a pair of main and reference images, this task attempts to answer several questions on both diseases and, more importantly, the differences between them. This is consistent with the radiologist’s diagnosis practice that compares the current image with the reference before concluding the report. We collect a new dataset, namely MIMIC-Diff-VQA, including 700,703 QA pairs from 164,324 pairs of main and reference images. Compared to existing medical VQA datasets, our questions are tailored to the Assessment Diagnosis-Intervention-Evaluation treatment procedure used …

Comparison Of Physics-Based Deformable Registration Methods For Image-Guided Neurosurgery, Nikos Chrisochoides, Yixun Liu, Fotis Drakopoulos, Andriy Kot, Panos Foteinos, Christos Tsolakis, Emmanuel Billias, Olivier Clatz, Nicholas Ayache, Andrey Fedorov, Alex Golby, Peter Black, Ron Kikinis

Computer Science Faculty Publications

This paper compares three finite element-based methods used in a physics-based non-rigid registration approach and reports on the progress made over the last 15 years. Large brain shifts caused by brain tumor removal affect registration accuracy by creating point and element outliers. A combination of approximation- and geometry-based point and element outlier rejection improves the rigid registration error by 2.5 mm and meets the real-time constraints (4 min). In addition, the paper raises several questions and presents two open problems for the robust estimation and improvement of registration error in the presence of outliers due to sparse, noisy, and incomplete …

Special Section Editorial: Artificial Intelligence For Medical Imaging In Clinical Practice, Claudia Mello-Thoms, Karen Drukker, Sian Taylor-Phillips, Khan Iftekharuddin, Marios Gavrielides

Electrical & Computer Engineering Faculty Publications

This editorial introduces the JMI Special Section on Artificial Intelligence for Medical Imaging in Clinical Practice.

Computer Aided Diagnosis System For Breast Cancer Using Deep Learning., Asma Baccouche

Electronic Theses and Dissertations

The recent rise of big data technology surrounding the electronic systems and developed toolkits gave birth to new promises for Artificial Intelligence (AI). With the continuous use of data-centric systems and machines in our lives, such as social media, surveys, emails, reports, etc., there is no doubt that data has gained the center of attention by scientists and motivated them to provide more decision-making and operational support systems across multiple domains. With the recent breakthroughs in artificial intelligence, the use of machine learning and deep learning models have achieved remarkable advances in computer vision, ecommerce, cybersecurity, and healthcare. Particularly, numerous …

Role Of Deep Learning Techniques In Non-Invasive Diagnosis Of Human Diseases., Hisham Abouelseoud Elsayem Abdeltawab

Electronic Theses and Dissertations

Machine learning, a sub-discipline in the domain of artificial intelligence, concentrates on algorithms able to learn and/or adapt their structure (e.g., parameters) based on a set of observed data. The adaptation is performed by optimizing over a cost function. Machine learning obtained a great attention in the biomedical community because it offers a promise for improving sensitivity and/or specificity of detection and diagnosis of diseases. It also can increase objectivity of the decision making, decrease the time and effort on health care professionals during the process of disease detection and diagnosis. The potential impact of machine learning is greater than …

Medical Image Segmentation With Deep Convolutional Neural Networks, Chuanbo Wang

Theses and Dissertations

Medical imaging is the technique and process of creating visual representations of the body of a patient for clinical analysis and medical intervention. Healthcare professionals rely heavily on medical images and image documentation for proper diagnosis and treatment. However, manual interpretation and analysis of medical images are time-consuming, and inaccurate when the interpreter is not well-trained. Fully automatic segmentation of the region of interest from medical images has been researched for years to enhance the efficiency and accuracy of understanding such images. With the advance of deep learning, various neural network models have gained great success in semantic segmentation and …

Segmentation With Super Images: A New 2d Perspective On 3d Medical Image Analysis, Ikboljon Sobirov, Numan Saeed, Mohammad Yaqub

Computer Vision Faculty Publications

Deep learning is showing an increasing number of audience in medical imaging research. In the segmentation task of medical images, we oftentimes rely on volumetric data, and thus require the use of 3D architectures which are praised for their ability to capture more features from the depth dimension. Yet, these architectures are generally more ineffective in time and compute compared to their 2D counterpart on account of 3D convolutions, max pooling, up-convolutions, and other operations used in these networks. Moreover, there are limited to no 3D pretrained model weights, and pretraining is generally challenging. To alleviate these issues, we propose …

Multimodal Multi-Head Convolutional Attention With Various Kernel Sizes For Medical Image Super-Resolution, Mariana-Iuliana Georgescu, Radu Tudor Ionescu, Andreea-Iuliana Miron, Olivian Savencu, Nicolae Verga, Nicolae-Cătălin Ristea, Fahad Shabaz Khan

Computer Vision Faculty Publications

Super-resolving medical images can help physicians in providing more accurate diagnostics. In many situations, computed tomography (CT) or magnetic resonance imaging (MRI) techniques output several scans (modes) during a single investigation, which can jointly be used (in a multimodal fashion) to further boost the quality of super-resolution results. To this end, we propose a novel multimodal multi-head convolutional attention module to super-resolve CT and MRI scans. Our attention module uses the convolution operation to perform joint spatial-channel attention on multiple concatenated input tensors, where the kernel (receptive field) size controls the reduction rate of the spatial attention and the number …

An Ensemble Approach For Patient Prognosis Of Head And Neck Tumor Using Multimodal Data, Numan Saeed, Roba Al Majzoub, Ikboljon Sobirov, Mohammad Yaqub

Computer Vision Faculty Publications

Accurate prognosis of a tumor can help doctors provide a proper course of treatment and, therefore, save the lives of many. Tradi-tional machine learning algorithms have been eminently useful in crafting prognostic models in the last few decades. Recently, deep learning algorithms have shown significant improvement when developing diag-nosis and prognosis solutions to different healthcare problems. However, most of these solutions rely solely on either imaging or clinical data. Utilizing patient tabular data such as demographics and patient med-ical history alongside imaging data in a multimodal approach to solve a prognosis task has started to gain more interest recently and …

Deep-Precognitive Diagnosis: Preventing Future Pandemics By Novel Disease Detection With Biologically-Inspired Conv-Fuzzy Network, Aviral Chharia, Rahul Upadhyay, Vinay Kumar, Chao Cheng, Jing Zhang, Tianyang Wang, Min Xu

Computer Vision Faculty Publications

Deep learning-based Computer-Aided Diagnosis has gained immense attention in recent years due to its capability to enhance diagnostic performance and elucidate complex clinical tasks. However, conventional supervised deep learning models are incapable of recognizing novel diseases that do not exist in the training dataset. Automated early-stage detection of novel infectious diseases can be vital in controlling their rapid spread. Moreover, the development of a conventional CAD model is only possible after disease outbreaks and datasets become available for training (viz. COVID-19 outbreak). Since novel diseases are unknown and cannot be included in training data, it is challenging to recognize them …

Automatic Segmentation Of Head And Neck Tumor: How Powerful Transformers Are?, Ikboljon Sobirov, Otabek Nazarov, Hussain Alasmawi, Mohammad Yaqub

Computer Vision Faculty Publications

Cancer is one of the leading causes of death worldwide, and head and neck (H&N) cancer is amongst the most prevalent types. Positron emission tomography and computed tomography are used to detect and segment the tumor region. Clinically, tumor segmentation is extensively time-consuming and prone to error. Machine learning, and deep learning in particular, can assist to automate this process, yielding results as accurate as the results of a clinician. In this research study, we develop a vision transformers-based method to automatically delineate H&N tumor, and compare its results to leading convolutional neural network (CNN)-based models. We use multi-modal data …

Is Contrastive Learning Suitable For Left Ventricular Segmentation In Echocardiographic Images?, Mohamed Saeed, Rand Muhtaseb, Mohammad Yaqub

Computer Vision Faculty Publications

Contrastive learning has proven useful in many applications where access to labelled data is limited. The lack of annotated data is particularly problematic in medical image segmenta-tion as it is difficult to have clinical experts manually annotate large volumes of data. One such task is the segmentation of cardiac structures in ultrasound images of the heart. In this paper, we argue whether or not contrastive pretraining is helpful for the segmentation of the left ventricle in echocardiography images. Furthermore, we study the effect of this on two segmentation networks, DeepLabV3, as well as the commonly used segmentation net-work, UNet. Our …

Challenges In Covid-19 Chest X-Ray Classification: Problematic Data Or Ineffective Approaches?, Muhammad Ridzuan, Ameera Ali Bawazir, Ivo Gollini Navarrete, Ibrahim Almakky, Mohammad Yaqub

Computer Vision Faculty Publications

The value of quick, accurate, and confident diagnoses cannot be undermined to mitigate the effects of COVID-19 infection, particularly for severe cases. Enormous effort has been put towards developing deep learning methods to classify and detect COVID-19 infections from chest radiography images. However, recently some questions have been raised surrounding the clinical viability and effectiveness of such methods. In this work, we carry out extensive experiments on a large COVID-19 chest X-ray dataset to investigate the challenges faced with creating reliable solutions from both the data and machine learning perspectives. Accordingly, we offer an in-depth discussion into the challenges faced …

Deep Learning For Task-Based Image Quality Assessment In Medical Imaging, Weimin Zhou

McKelvey School of Engineering Theses & Dissertations

It has been advocated to use objective measures of image quality (IQ) for assessing and optimizing medical imaging systems. Objective measures of IQ quantify the performance of an observer at a specific diagnostic task. Binary signal detection tasks and joint signal detection and localization (detection-localization) tasks are commonly considered in medical imaging. When optimizing imaging systems for binary signal detection tasks, the performance of the Bayesian Ideal Observer (IO) has been advocated for use as a figure-of-merit (FOM). The IO maximizes the observer performance that is summarized by the receiver operating characteristic (ROC) curve. When signal detection-localization tasks are considered, …

Design Of A Novel Wearable Ultrasound Vest For Autonomous Monitoring Of The Heart Using Machine Learning, Garrett G. Goodman

Browse all Theses and Dissertations

As the population of older individuals increases worldwide, the number of people with cardiovascular issues and diseases is also increasing. The rate at which individuals in the United States of America and worldwide that succumb to Cardiovascular Disease (CVD) is rising as well. Approximately 2,303 Americans die to some form of CVD per day according to the American Heart Association. Furthermore, the Center for Disease Control and Prevention states that 647,000 Americans die yearly due to some form of CVD, which equates to one person every 37 seconds. Finally, the World Health Organization reports that the number one cause of …

A Study Of Machine Learning And Deep Learning Models For Solving Medical Imaging Problems, Fadi G. Farhat

Theses

Application of machine learning and deep learning methods on medical imaging aims to create systems that can help in the diagnosis of disease and the automation of analyzing medical images in order to facilitate treatment planning. Deep learning methods do well in image recognition, but medical images present unique challenges. The lack of large amounts of data, the image size, and the high class-imbalance in most datasets, makes training a machine learning model to recognize a particular pattern that is typically present only in case images a formidable task.

Experiments are conducted to classify breast cancer images as healthy or …

A U-Net Deep Learning Framework For High Performance Vessel Segmentation In Paitents With Cerebrovascular Disease, Michelle Livne, Jana Rieger, Orhun Utku Aydin, Abdel Aziz Taha, Ela Maria Akay, Tabea Kossen, Jan Sobesky, John D. Kelleher, Kristian Hildebrand, Dietmar Frey, Vince I. Madai

Articles

Brain vessel status is a promising biomarker for better prevention and treatment in cerebrovascular disease. However, classic rule-based vessel segmentation algorithms need to be hand-crafted and are insufficiently validated. A specialized deep learning method—the U-net—is a promising alternative. Using labeled data from 66 patients with cerebrovascular disease, the U-net framework was optimized and evaluated with three metrics: Dice coefficient, 95% Hausdorff distance (95HD) and average Hausdorff distance (AVD). The model performance was compared with the traditional segmentation method of graph-cuts. Training and reconstruction was performed using 2D patches. A full and a reduced architecture with less parameters were trained. We …

Lung Segmentation In Chest Radiographs Using Fully Convolutional Networks, Rahul Hooda, Ajay Mittal, Sanjeev Sofat

Turkish Journal of Electrical Engineering and Computer Sciences

Automated segmentation of medical images that aims at extracting anatomical boundaries is a fundamental step in any computer-aided diagnosis (CAD) system. Chest radiographic CAD systems, which are used to detect pulmonary diseases, first segment the lung field to precisely define the region-of-interest from which radiographic patterns are sought. In this paper, a deep learning-based method for segmenting lung fields from chest radiographs has been proposed. Several modifications in the fully convolutional network, which is used for segmenting natural images to date, have been attempted and evaluated to finally evolve a network fine-tuned for segmenting lung fields. The testing accuracy and …

Large-Scale Deep Learning With Application In Medical Imaging And Bio-Informatics, Zheng Xu

Computer Science and Engineering Dissertations

With the recent advancement of the deep learning technology in the artificial intelligence area, nowadays people's lives have been drastically changed. However, the success of deep learning technology mostly relies on large-scale high-quality data-sets. The complexity of deeper model and larger scale datasets have brought us significant challenges. Inspired by this trend, in this dissertation, we focus on developing efficient and effective large-scale deep learning techniques in solving real-world problems, like cell detection in hyper-resolution medical image or drug screening from millions of compound candidates. With respect to the hyper-resolution medical imaging cell detection problem, the challenges are mainly the …

Deep Learning Based Multi-Label Classification For Surgical Tool Presence Detection In Laparoscopic Videos, Ashwin Raju

Computer Science and Engineering Theses

Laparoscopic surgery, Modern surgery, where the surgery is performed far away from the patient by inserting small incisions on the patient's body and the surgery is performed with a help of a video recorder and through which the doctor performs the surgery. The computer assisted intervention are increasing exponentially and the need for accurate and reliable intervention is very important because of the domain which is very critical. Efforts have made to develop a system that is both fast and accurate approach but it is still an active area of research due its importance. Some applications which involve identifying the …

Lagrangian Analysis Of Vector And Tensor Fields: Algorithmic Foundations And Applications In Medical Imaging And Computational Fluid Dynamics, Zi'ang Ding

Open Access Dissertations

Both vector and tensor fields are important mathematical tools used to describe the physics of many phenomena in science and engineering. Effective vector and tensor field visualization techniques are therefore needed to interpret and analyze the corresponding data and achieve new insight into the considered problem. This dissertation is concerned with the extraction of important structural properties from vector and tensor datasets. Specifically, we present a unified approach for the characterization of distinguished manifolds that form the skeleton of vector and tensor fields and play a key role in understanding their properties.

This dissertation makes several important contributions in this …

Vascular Tree Structure: Fast Curvature Regularization And Validation, Egor Chesakov

Electronic Thesis and Dissertation Repository

This work addresses the challenging problem of accurate vessel structure analysis in high resolution 3D biomedical images. Typical segmentation methods fail on recent micro-CT data sets resolving near-capillary vessels due to limitations of standard first-order regularization models. While regularization is needed to address noise and partial volume issues in the data, we argue that extraction of thin tubular structures requires higher-order curvature-based regularization. There are no standard segmentation methods regularizing surface curvature in 3D that could be applied to large 3D volumes. However, we observe that standard measures for vessels structure are more concerned with topology, bifurcation angles, and other …

Medical Imaging Specialists And 3d: A Domain Perspective On Mobile 3d Interactions, Teddy Seyed, Frank Maurer, Francisco Marinho Rodrigues, Anthony Tang

Research Collection School Of Computing and Information Systems

3D volumetric medical images, such as MRIs, are commonly explored and interacted with by medical imaging experts using systems that require keyboard and mouse-based techniques. These techniques have presented challenges for medical imaging specialists: 3D spatial navigation is difficult, in addition to the detailed selection and analysis of 3D medical images being difficult due to depth perception and occlusion issues. In this work, we explore a potential solution to these challenges by using tangible interaction techniques with a mobile device to simplify 3D interactions for medical imaging specialists. We discuss preliminary observations from our design sessions with medical imaging specialists …

Design And Optimization Of Four-Dimensional Cone-Beam Computed Tomography In Image-Guided Radiation Therapy, Moiz Ahmad

Dissertations & Theses (Open Access)

The influence of respiratory motion on patient anatomy poses a challenge to accurate radiation therapy, especially in lung cancer treatment. Modern radiation therapy planning uses models of tumor respiratory motion to account for target motion in targeting. The tumor motion model can be verified on a per-treatment session basis with four-dimensional cone-beam computed tomography (4D-CBCT), which acquires an image set of the dynamic target throughout the respiratory cycle during the therapy session. 4D-CBCT is undersampled if the scan time is too short. However, short scan time is desirable in clinical practice to reduce patient setup time. This dissertation presents the …

Procedural Wound Geometry And Blood Flow Generation For Medical Training Simulators, Rifat Aras, Yuzhong Shen, Jiang Li, David R. Holmes Iii (Ed.), Kenneth H. Wong (Ed.)

Electrical & Computer Engineering Faculty Publications

Efficient application of wound treatment procedures is vital in both emergency room and battle zone scenes. In order to train first responders for such situations, physical casualty simulation kits, which are composed of tens of individual items, are commonly used. Similar to any other training scenarios, computer simulations can be effective means for wound treatment training purposes. For immersive and high fidelity virtual reality applications, realistic 3D models are key components. However, creation of such models is a labor intensive process. In this paper, we propose a procedural wound geometry generation technique that parameterizes key simulation inputs to establish the …

Framework To Secure Cloud-Based Medical Image Storage And Management System Communications, Timothy James Rostrom

Theses and Dissertations

Picture Archiving and Communication Systems (PACS) have been traditionally constrained to the premises of the healthcare provider. This has limited the availability of these systems in many parts of the world and mandated major costs in infrastructure for those who employ them. Public cloud services could be a solution that eases the cost of ownership and provides greater flexibility for PACS implementations. This could make it possible to bring medical imaging services to places where it was previously unavailable and reduce the costs associated with these services for those who utilize them. Moving these systems to public cloud infrastructure requires …

The Design Of A Computer System To Determine The Causes Of Edema Using Magnetic Resonance Spectroscopy, Carl Allen Fink

LSU Master's Theses

Diabetes is a growing problem in the U.S.A., closely linked to the current obesity epidemic. Two common complications of diabetes, osteomyelitis of the foot, and Charcot's joint, are impossible to differentiate via traditional Magnetic Resonance Imaging. The background of Magnetic Resonance Spectroscopy, which transforms the time-domain MRI signal into the frequency domain spectrum, is explored, and its use to aid in this differentiation is proposed. Artificial Neural Networks can be employed to evaluate the MRS data and to automate the process.