Physical Sciences and Mathematics Commons^™

Two Highly Diverse Studies In Computing: A Vitruvian Framework For Distribution And A Search Approach To Cancer Therapies, Brian G. Smith

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Solid cancer tumors must recruit new blood vessels for growth and maintenance. Discovering drugs that block this tumor-induced development of new blood vessels (angiogenesis) is an important approach in cancer treatment. However, the complexity of angiogenesis and the difficulty in implementing and evaluating medical changes prevent the discovery of novel and effective new therapies. This paper presents a massively parallel computational search-based approach for the discovery of novel potential cancer treatments, using a high fidelity simulation of angiogenesis. Discovering new therapies is viewed as multi-objective combinatorial optimization over two competing objectives: minimizing the medical cost of the intervention while minimizing …