Physical Sciences and Mathematics Commons^™

Alignment For Comprehensive Two-Dimensional Gas Chromatography (Gcxgc) With Global, Low-Order Polynomial Transformations, Davis Rempe, Stephen Reichenbach, Stephen Scott

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As columns age and differ between systems, retention times for GC x GC may vary between runs. In order to properly analyze chromatograms, it is often desirable to align chromatographic features between chromatograms. This alignment can be characterized by a mapping of retention times from one chromatogram to the retention times of another chromatogram. Alignment methods can be classified as global or local, i.e., whether the geometric differences between chromatograms are characterized by a single function for the entire chromatogram or by a combination of many functions for different regions of the chromatogram. Previous work has shown that global, low-degree …