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Full-Text Articles in Physical Sciences and Mathematics
The Cytotoxic Effect Of 2-Acylated-1,4-Naphthohydroquinones On Leukemia/Lymphoma Cells, Diego A. Pedroza, Fernando De Leon, Armando Varela-Ramirez, Carolina Lerma, Renato J. Aguilera, Shizue Mito
The Cytotoxic Effect Of 2-Acylated-1,4-Naphthohydroquinones On Leukemia/Lymphoma Cells, Diego A. Pedroza, Fernando De Leon, Armando Varela-Ramirez, Carolina Lerma, Renato J. Aguilera, Shizue Mito
Chemistry Faculty Publications and Presentations
Here, we tested seven 2-acylated-1,4-hydronaphthoquinones for their cytotoxic effects on a panel of cancer lymphoma/leukemia cells and compared to a non-cancer origin cell line. Several naphthohydroquinones exhibited selective cytotoxic effects on lymphoma/leukemia cells with lowest activity on non-cancer cells. The mode of cell death induced by an acylated naphthohydroquinone, which has a long alkyl chain, was found to be via apoptosis. Furthermore, the naphthohydroquinone provoked mitochondria depolarization and activation of its downstream effector, caspase-3, thus implicating the intrinsic apoptotic pathway as its mechanism to exert cell death.