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Full-Text Articles in Physical Sciences and Mathematics
Controlling Reductive Elimination From Novel I(Iii) Salts Using A Secure Method, Joseph W. Graskemper
Controlling Reductive Elimination From Novel I(Iii) Salts Using A Secure Method, Joseph W. Graskemper
Department of Chemistry: Dissertations, Theses, and Student Research
Positron Emission Tomography (PET) is a valuable clinical, research, and diagnostic technique for human and animal organ imaging. The current market for PET in the United States is $500 million per year and is projected to be $5.4 billion per year globally by 2015. To synthesize labeled radiotracers, we are most interested in using 18F as the isotope of choice because it is a nearly ideal positron emitting radionuclide.
Electron-rich aromatic substrates can be particularly difficult to fluorinate. We show that reductive elimination of I(III) diaryliodonium salts provide increased fluorination of electron-rich aromatic substrates. Modest yields of fluorinated product …