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Full-Text Articles in Physical Sciences and Mathematics
Developing Novel Electrospray Ionization Mass Spectrometry (Esi Ms) Techniques To Study Higher Order Structure And Interaction Of Biopolymers, Agya K. Frimpong
Developing Novel Electrospray Ionization Mass Spectrometry (Esi Ms) Techniques To Study Higher Order Structure And Interaction Of Biopolymers, Agya K. Frimpong
Open Access Dissertations
Mass spectrometry has enjoyed enormous popularity over the years for studying biological systems. The theme of this dissertation was to develop and use mass spectrometry based tools to solve five biologically oriented problems associated with protein architecture and extend the utility of these tools to study protein polymer conjugation. The first problem involved elucidating the false negatives of how proteins with few basic residues, forms highly charged ions in electrospray ionization mass spectrometry (ESI MS). This study showed that the unfolding of polypeptide chains in solution leads to the emergence of highly charged protein ions in ESI MS mass spectra, …
The Development Of An Optimized System Of Narcotic And Explosive Contraband Mimics For Calibration And Training Of Biological Detectors, Michael S. Macias
The Development Of An Optimized System Of Narcotic And Explosive Contraband Mimics For Calibration And Training Of Biological Detectors, Michael S. Macias
FIU Electronic Theses and Dissertations
Current commercially available mimics contain varying amounts of either the actual explosive/drug or the chemical compound of suspected interest by biological detectors. As a result, there is significant interest in determining the dominant chemical odor signatures of the mimics, often referred to as pseudos, particularly when compared to the genuine contraband material. This dissertation discusses results obtained from the analysis of drug and explosive headspace related to the odor profiles as recognized by trained detection canines. Analysis was performed through the use of headspace solid phase microextraction in conjunction with gas chromatography mass spectrometry (HS-SPME-GC-MS). Upon determination of specific odors, …