Open Access. Powered by Scholars. Published by Universities.®
Physical Sciences and Mathematics Commons™
Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 5 of 5
Full-Text Articles in Physical Sciences and Mathematics
Tailoring The Surface-Coating Of Gold Nanoparticles For Bio-Applications, Partha S. Ghosh
Tailoring The Surface-Coating Of Gold Nanoparticles For Bio-Applications, Partha S. Ghosh
Open Access Dissertations
Functionalized gold nanoparticles (AuNPs) provide an excellent scaffold for numerous biological applications. In these systems, the gold core imparts stability to the assembly, while the monolayer allows tuning of surface characteristics such as charge and hydrophobicity. The nano-scale size and tunable surface properties have made them an ideal candidate for manipulating protein-protein/protein-nucleic acid interactions, and delivery of therapeutics. In this thesis work, it has been demonstrated how the surface coating plays an important role in achieving a desired goal. Using organic synthesis as a tool, the monolayer was tailored to afford useful particles with biocompatibility and the ability to respond …
Intermolecular Electron Transfer Reactivity And Dynamics Of Cytochrome C – Nanoparticle Adducts, Adrienne M. Carver
Intermolecular Electron Transfer Reactivity And Dynamics Of Cytochrome C – Nanoparticle Adducts, Adrienne M. Carver
Open Access Dissertations
Interprotein electron transfer (ET) is crucial for natural energy conversion and a fundamental reaction in the pursuit of understanding the broader problem of proteinprotein interactions and reactivity. Simplifying the complicated nature of these natural systems has driven development of biomimetic approaches. Functionalized gold nanoparticles offer simplified, tunable surfaces that can serve as a proxy to study the reactivity and dynamics of proteins. Amino-acid functionalized gold nanoparticles (Au-TX) served as a complementary partner to cytochrome c (Cyt c) and catalyzed its ET reactivity without altering the native structure. Redox mediator and EPR experiments confirmed that the redox potential and coordination environment …
Engineering The Nanoparticle Surface For Protein Recognition And Applications, Mrinmoy De
Engineering The Nanoparticle Surface For Protein Recognition And Applications, Mrinmoy De
Open Access Dissertations
Proteins and nanoparticles (NPs) provide a promising platform for supramolecular interaction. We are currently exploring both fundamental and applied aspects of this interaction. On the fundamental side, we have fabricated a series of water-soluble anionic and cationic NPs to interact with cationic and anionic proteins respectively. A Varity of studies such as, activity assay, fluorescence titration, isothermal titration calorimetry etc. were carried out to quantify the binding properties of these functional NPs with those proteins. Those studies reveal the prospect of tuning the affinity between the nanoparticles and proteins by the surface modification. On the application side, we have used …
Investigation Of Photophysical And Photochemical Processes In Conjugated Polymer Nanoparticles By Single Particle And Ensemble Spectroscopy, Craig Szymanski
Investigation Of Photophysical And Photochemical Processes In Conjugated Polymer Nanoparticles By Single Particle And Ensemble Spectroscopy, Craig Szymanski
All Dissertations
Single molecule imaging has emerged as a powerful tool in a range of applications, but the field is limited by a lack of fluorescent probes with sufficient brightness and photostability for many demanding applications such as tracking of single biomolecules in cells and tissues at video rate with 1 nm spatial resolution. Conjugated polymers hold great promise as a solution to these issues, with a high density of π electrons and variety of chemistries, allowing efficient and tunable absorption of light. This dissertation describes the development and characterization of a novel type of nanoparticle composed of conjugated polymer called CPdots. …
Applying Scanning Probe Microscopy For The Investigation Of Molecular Self-Assembly Mechanisms And Properties Of Designed Nanomaterials, Algernon Tremayne Kelley
Applying Scanning Probe Microscopy For The Investigation Of Molecular Self-Assembly Mechanisms And Properties Of Designed Nanomaterials, Algernon Tremayne Kelley
LSU Doctoral Dissertations
Scanning probe microscopy (SPM) for conducting surface characterizations of nanomaterials and molecular self-assembly processes is emerging as an important contribution in nanotechnology, especially towards the design of molecular electronic devices. Another area of importance is the characterization of the properties of nanomaterials for fundamental understanding of structure-function inter-relationships. Understanding the properties and behavior of molecules and finding approaches to control surface self-organization through nanolithography provides essential information for the development of workable applications for nanotechnology. This dissertation describes the methodologies of AFM for characterizing molecules and nanostructures produced with scanning probe lithography (SPL). Automated software for nanografting and nanoshaving produce …