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Physical Sciences and Mathematics Commons

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Full-Text Articles in Physical Sciences and Mathematics

Chimeric Rhinoviruses Displaying Mper Epitopes Elicit Anti-Hiv Neutralizing Responses, Guohua Yi, Mauro Lapelosa, Rachel Bradley, Thomas M. Mariano, Denise Elsasser Dietz, Scott Hughes, Terri Wrin, Chris Petropoulos, Emilio Gallicchio, Ronald M. Levy, Eddy Arnold, Gail Ferstandig Arnold Sep 2013

Chimeric Rhinoviruses Displaying Mper Epitopes Elicit Anti-Hiv Neutralizing Responses, Guohua Yi, Mauro Lapelosa, Rachel Bradley, Thomas M. Mariano, Denise Elsasser Dietz, Scott Hughes, Terri Wrin, Chris Petropoulos, Emilio Gallicchio, Ronald M. Levy, Eddy Arnold, Gail Ferstandig Arnold

Publications and Research

Background: The development of an effective AIDS vaccine has been a formidable task, but remains a critical necessity. The well conserved membrane-proximal external region (MPER) of the HIV-1 gp41 glycoprotein is one of the crucial targets for AIDS vaccine development, as it has the necessary attribute of being able to elicit antibodies capable of neutralizing diverse isolates of HIV.

Methodology/Principle Findings: Guided by X-ray crystallography, molecular modeling, combinatorial chemistry, and powerful selection techniques, we designed and produced six combinatorial libraries of chimeric human rhinoviruses (HRV) displaying the MPER epitopes corresponding to mAbs 2F5, 4E10, and/or Z13e1, connected to an immunogenic …


Reality Of Chemistry Is Far From Stereotypes, Aldemaro Romero Jr. Jan 2013

Reality Of Chemistry Is Far From Stereotypes, Aldemaro Romero Jr.

Publications and Research

No abstract provided.


Chemist Breaks With The Usual Stereotypes, Aldemaro Romero Jr. Jan 2013

Chemist Breaks With The Usual Stereotypes, Aldemaro Romero Jr.

Publications and Research

No abstract provided.


Winsor & Newton Original Handbooks: Asurface-Enhanced Raman Scattering (Sers) Andraman Spectral Database Of Dyes From Modernwatercolor Pigments, Federica Pozzi, John R. Lombardi, Marco Leona Jan 2013

Winsor & Newton Original Handbooks: Asurface-Enhanced Raman Scattering (Sers) Andraman Spectral Database Of Dyes From Modernwatercolor Pigments, Federica Pozzi, John R. Lombardi, Marco Leona

Publications and Research

Background

Winsor & Newton Ltd. has been one of the main fine art products providers since its establishment in 1832, being responsible for the manufacture of a wide assortment of materials ranging from oils and pigments to brushes and papers. All the items produced over the years have been indexed in a comprehensive historical archive. Original Winsor & Newton handbooks are a powerful resource which can offer insight into the world of artists’ materials, and knowledge of artists’ choices through the identification of substances employed to obtain particular colors. Scientific analyses of various kinds have been carried out on Winsor …