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Full-Text Articles in Physical Sciences and Mathematics
Effects Of Crowding Agents On I-Motif Dna, Hayden Brines
Effects Of Crowding Agents On I-Motif Dna, Hayden Brines
Honors Theses
Deoxyribonucleic acid (DNA) is a well-known double stranded, helical, biological molecule. In addition to its more commonly known structure, DNA can also form more complicated structures like G-quadruplexes and i-motifs (iM). The iMs are formed by cytosine rich DNA and are a four stranded structure that is typically looped around itself. The iM formation is typically pH-dependent and is favored in more acidic conditions; the pKa value is approximately 6.5. This pKa value allows for potential in vivo formation, since the cells have a pH of approximately 7.3. Due to this, iMs are thought to be powerful, innovative molecules for …
Mechanisms Of Cytotoxicity Of Diepoxybutane, Epichlorohydrin And 1-(Chloroethenyl)Oxirane, Rebecca D. Kamins
Mechanisms Of Cytotoxicity Of Diepoxybutane, Epichlorohydrin And 1-(Chloroethenyl)Oxirane, Rebecca D. Kamins
Honors Theses
Diepoxybutane (DEB), epichlorohydrin (ECH), and 1-(chloroethenyl)oxirane (COX) are small molecules that can form DNA interstrand cross-links. All three of these compounds are, or are metabolites of, industrial chemicals linked to cancer. Additionally, DEB is a metabolite of treosulfan, an anti-cancer drug. We are trying to determine why some of these compounds cause cancer and some can also cure cancer. To do so, we are attempting to link cytotoxicity, cross-linking efficiency, and apoptotic potential of the three compounds to see if any correlations exist. The purpose of this project was to quantify apoptotic potential of DEB, ECH and COX. This was …
Metal Ion Stabilization Of G-Tetrads Containing 6-Thioguanosine, Julia Drees
Metal Ion Stabilization Of G-Tetrads Containing 6-Thioguanosine, Julia Drees
Honors Theses
As alternative structures to the double helix, G-tetrads are thought to occur in DNA with many repeating deoxyguanosines (dG). These tetrads have one dG on each corner of a plane and can stack into tetraplexes that can be aptamers and may be found in telomeres. G-tetrads are destabilized by incorporation of 6-thiodeoxyguanosine (?sdG). Addition of metal ions that bind sulfur may stabilize these ?sdG-tetrads. We have carried out a survey of metal ion titrations into ?sG. Stable ?sG:MD? complexes were found for Hg2? (2:1), Cd2? (4:1), Ag2? (0.7:1) and Pt2? (thought to be 2:1). UV/Visible spectrophotometry indicates that G-tetrads containing …
Dna Interstrand Crosslinking Efficiencies, Sequence Preferences, And Organic Syntheses Of Diepoxide Metabolites In Fixation, Sara Charnecki
Dna Interstrand Crosslinking Efficiencies, Sequence Preferences, And Organic Syntheses Of Diepoxide Metabolites In Fixation, Sara Charnecki
Honors Theses
Molecular Basis of Cancer: Cancer, a disease that has had a devastating and frightening impact on current society in the midst of a chemical revolution, represents a class of diseases comprising over 200 known types that affect various regions of the mammalian body (Farmer & Walker, 1985). This disease strikes randomly and is often diagnosed after the disease has progressed beyond present treatment capabilities. Cancer is the result of irregularities in growth, reproduction, and differentiation of cells due to pennanent flaws in genetic information. Mutations caused by environmental factors can be compounded over time to cause carcinomas of different tissues. …
Syntheses Of Cross-Linking Agents, Molecular Modeling Of Oligonucleotides And Polypeptide-Ion Complexes, Michael J. Yunes
Syntheses Of Cross-Linking Agents, Molecular Modeling Of Oligonucleotides And Polypeptide-Ion Complexes, Michael J. Yunes
Honors Theses
Each section of this thesis will be subdivided into three parts encompassing all of the research in which I have been involved during the past three years. These will be referred to under the headings "Syntheses:' "Molecular Modeling," and "Cross-linking Efficiencies." Each of these subdivisions may have divisions within them when necessary in order to fully detail the research.