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Articles 1 - 12 of 12
Full-Text Articles in Physical Sciences and Mathematics
Synthesis Of A Dirhodium Tetraphosphine Catalyst And The Effect Of Various H2/Co Ratios On The Catalyst, Christina Joanne Sweeney
Synthesis Of A Dirhodium Tetraphosphine Catalyst And The Effect Of Various H2/Co Ratios On The Catalyst, Christina Joanne Sweeney
Honors Theses
No abstract provided.
Temperature And Magnetic Field Dependence Of The Electronic Excitations In The Nickel Chain Compound Nino, Lucas Laviolet
Temperature And Magnetic Field Dependence Of The Electronic Excitations In The Nickel Chain Compound Nino, Lucas Laviolet
Honors Theses
Temperature and magnetic field dependent absorbance spectra were taken on the Ni2+ chain compound NINO (Ni(C?H??N?)?NO?(ClO?)) in the range from 8,500 to 25,000 cm-?. The identification of an effective C?v symmetry about the nickel ions is supported by assignment of the low temperature absorbance bands. The intensity of many bands is found to be temperature dependent, and in several bands, a shift to higher energy is observed at lower temperatures. A correlation is noted between the field dependence of the spin forbidden electronic transitions and the magnetic properties of NINO. Below a crossover magnetic field, Hc ? 10 T, the …
Foundations And Interpretations Of Quantum Mechanics, Cory Johnson
Foundations And Interpretations Of Quantum Mechanics, Cory Johnson
Honors Theses
The first famous thought experiment of Einstein gives rise to his theories of relativity, the bedrock of modern astrophysics and cosmology. His second famous thought experiment begins the investigation into the foundations of quantum mechanics. It leads to a paradox, inspiring various 'no-go' theorems proven by Bell, Kochen, and Specker. Physicists and philosophers worldwide become increasingly dissatisfied with the probabilistic complementarity interpretation (Born-Bohr) and eventually offer their own accounts of the theory. By the end of the 20th century two alternative approaches stand out as the best candidates: Both the hidden variables interpretation (de Broglie-Bohm) and the many worlds interpretation …
Effects Of Context Of Natural And Artifactual Objects On Categorization, Linsey Walker
Effects Of Context Of Natural And Artifactual Objects On Categorization, Linsey Walker
Honors Theses
Categorization of animals and vehicles in different contexts was investigated in three experiments using event related potentials (ERPs). The presence of a background and congruency of the background in relation to the object were both manipulated in order to determine the effects of context on visual processing. In Experiment 1, adults were presented with images of animals and vehicles in two conditions: situated in a congruent context (e.g. an animal in a field) and in the absence of a context (an animal in a white homogeneous background). In experiment 2, adults were presented with images of animals and vehicles in …
The Determination Of The Electronic Structure And Geometries Of Boron And Boron Mononitrogen Clusters Using An Adaptive, Kink-Based Path Integral Approach To Quantum Mechanics, Shawn Wilkinson
Honors Theses
No abstract provided.
Inhibition Of Cellular Thioredoxin Reductase By The Anticancer Prodrug Cloretazine, Tyler R. Schleicher
Inhibition Of Cellular Thioredoxin Reductase By The Anticancer Prodrug Cloretazine, Tyler R. Schleicher
Honors Theses
Sulfonylhydrazines are a class of DNA alkylating drugs which also produce carbamoylating activity in situ. The carbamoylating species is of significance because it has shown to inhibit important thiol-containing enzymes such as glutathione reductase (GR) and thioredoxin reductase (TrxR). TrxR catalyzes dithiol-disulfide exchange reactions on thioredoxin (Trx), which in turn catalyzes other reductive processes such as deoxyribonucleotide biosynthesis. In this study, we demonstrate that TrxR activity is strongly inhibited by the anticancer prodrug Cloretazine both in purified form and in leukemia cell lysates. This inhibition is specific to the carbamoylating activity of methylisocyanate (MiC). In contrast, another important oxidoreductase, glutathione …
Reactions Of Atomic Carbon With Acid Chlorides, Daniel B. Herrick
Reactions Of Atomic Carbon With Acid Chlorides, Daniel B. Herrick
Honors Theses
This thesis is the first report of reactions of atomic carbon with acid chlorides. Carbon is known to react with phosgene to afford dichlorocarbene. We report a similar reaction with carbon and acid chlorides, generating alkylchlorocarbenes. We examine both the nature of the carbene products generated through deoxygenation and the general reactivity of carbon with the acid chlorides. We report two ways in which carbon reacts with acid chlorides. First, as expected from prior work with phosgene, carbon deoxygenates the carbonyl group yielding alkylchlorcarbenes, which rearrange as expected. Second, carbon abstracts the chlorine, and generates the acyl radical, which, in …
Pressure Perturbation Calorimetry And Guest-Host Chemistry Of Ndmg And N-Map With P-Sulfonatocalix[6]Arene, Cassandra Newell
Pressure Perturbation Calorimetry And Guest-Host Chemistry Of Ndmg And N-Map With P-Sulfonatocalix[6]Arene, Cassandra Newell
Honors Theses
The aim of this project is to provide an explanation for recently obtained binding constants for two similar guest molecules, NDMG and N-MAP, with a p-sulfonatocalix[6]arene host in ammonium acetate buffer. This work was done primarily using pressure perturbation calorimetry, which is a technique that determines the coefficient of thermal expansion, α, which is in turn related to the solute molecule's effect on the order of the surrounding water molecules. A series of experiments were designed to test the effects of suspected confounding variables on the validity of PPC data. PPC was then used to study NDMG and N-MAP in …
Using Azahetercyclic Electrophiles To Synthesize Novel Bicyclooxacalixarenes And Oxacalix[2]N-Hexylnaphthalimide[2]Naphthyridines, Doug Rooke
Honors Theses
Various bicyclooxacalixarenes, tricyclooxacalixarenes and oxacalix[2]N-hexylnapthalimide[2]naphthyridines are synthesized via SnAr condensation. This research has involved synthesis optimization. The oxacalix[2]N-hexylnaphthalimide[2]naphthyridines have exhibited host-guest binding in fluorescence experiments. These compounds have been characterized by NMR spectroscopy as well as single crystal X-ray diffraction.
Photochemical Generation And Intramolecular Chemistry Of Β-Alkoxycarbenes, Kimberly Graves
Photochemical Generation And Intramolecular Chemistry Of Β-Alkoxycarbenes, Kimberly Graves
Honors Theses
The photolytic phenanthrene-based precursors for both β-methoxycarbene and β-ethoxycarbene were synthesized with and without a deuterium label attached to the a carbon. The incorporation of this deuterium label allowed distinction between a 1, 2-H shift and a 1, 2-O shift pathway to the respective alkyl vinyl ether, without the influence of a primary kinetic isotope effect. Photolyses of these precursors gave rearrangement products of the expected β-alkoxycarbenes. In the case of β-methoxycarbene, no methyl vinyl ether was observed due to its volatility. However, the appearance of aldehyde peaks in the NMR spectra, from an apparent further rearrangement to acetaldehyde through …
The Selective Synthesis Of Oxacalix[6]Arenes And The Exploration Of Azacalix[N]Arenes, W. Christian Crannell
The Selective Synthesis Of Oxacalix[6]Arenes And The Exploration Of Azacalix[N]Arenes, W. Christian Crannell
Honors Theses
Calix[n]arenes, cyclIc molecules composed of "n" benzene rings meta-linked by a methylene to form a macrocycle, are very prevalent jn the literature and enjoy a wide range of applications. However, the oxygen bridged and nitrogen bridged systems, oxacalllx[n)arenes and azacalix[n]arenes, respectively, are far less common because they are synthetically challenging. Furthermore, the selective synthesis of oxacalix[6]arene systems has not previously been well documented, but the systems can now be accessed in a facile approach disclosed here. The insight and knowledge gained from the synthesis of oxacalix{6]arenes has provided a foray into the synthesis of azacalix[nlarenes.
Effects Of The Anticancer Agent Cloretazine On Human Apurinic Endonuclease-1 Activity, Jennifer L. Bushee
Effects Of The Anticancer Agent Cloretazine On Human Apurinic Endonuclease-1 Activity, Jennifer L. Bushee
Honors Theses
The carbamolyating activity of Cloretazine, a novel anticancer prodrug, modifies protein function and acts synergistically with the choroethyalting species, which a1kylales DNA. The reactive subspecies responsible for carbamolylating activity is methyl isocyanate, which reacts with sulfhydryl groups and amines. DNA repair enzymes have been identified as potential targets for the modification by methyl isocyanate; in particular, base excision repair enzymes. Enzymes in DNA base excision repair include DNA polymerase beta (Pol ?) and apurinic/apyrimidic endonucease-l (APE/Ref-1). APE/Ref-1 hydrolyzes the 5' -phosphodiester DNA backbone from an abasic DNA template, where the base was excised by a DNA glycosylase. The entire nucleotide …