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Articles 1 - 13 of 13
Full-Text Articles in Physical Sciences and Mathematics
Iodination Of Aromatic Compounds, Paul T. Kabb
Iodination Of Aromatic Compounds, Paul T. Kabb
Honors Theses
Iodination of aromatic compounds was accomplished using the procedure given by Durand, with a few slight modifications introduced. Benzene was reacted with sulphuric acid, fuming sulphuric acid, and iodine to give hexaiodobenzene. Ethylbenzene was reacted with the mixture of sulphuric acids and iodine to give a mixture of less iodo-substituted products. Reduction using hydrogen atoms was accomplished. Hexaiodobenzene in the presence of dimethyl sulfoxide and sodium hydride was reduced to a mixture of less iodo-substituted products.
Synthesis Of N-Methyl-N-Benzyl-Beta-Chloro (Substituted Beta-Phenyl) Ethylamine Hychochloride, Mark Stuart Shulman
Synthesis Of N-Methyl-N-Benzyl-Beta-Chloro (Substituted Beta-Phenyl) Ethylamine Hychochloride, Mark Stuart Shulman
Honors Theses
β-haloalkyl amines are effective sympathetic blocking agents. An attempt was made to synthesize two β –haloakyl-amines, N-methyl, N-benzyl-β-chloro-β-(p-bromophenyl and 3,5 dichloro phenyl) ethylamine hydrochloride, in hopes that the compounds would have the pharmacological properties of a rapid onset, long duration, low toxicity, and few side effects. The basic criteria that β-haloalkylamine must have in order to display blocking properties are: tertiary amine, a β-haloakylamine group capable of forming an intermediate ethylenimonium ion, and an unsaturated ring substitute attached to the amine to allow ring stabilization. The compounds being synthesized display all these characteristics. The synthesis of N-methyl, N-benzyl- β-chloro β-(p-bromo-phenyl) …
Adrenergic Blocking Agents, Jeffrey Bruce Alifanz
Adrenergic Blocking Agents, Jeffrey Bruce Alifanz
Honors Theses
β-Haloalkylamines are a series of sympathetic blocking compounds. Phenoxybenzamine, the only commercially available β-haloalkylamine, goes under the trade name of dibenzyline and has an onset of sympathetic blocking effect of forty-five minutes and lasts for twenty-four to thirty-six hours. It requires a dose of 10-15 mg./kg. in previously anesthetized animals for full blocking effect and obviously its slowness of onset curtails its usefulness. N-Methyl-N-benzyl-β-chloro-β-phenyl-ethylaminehydrochloride also known as BMEA (for benzyl, methyl, phenethyl amine) differs by having an onset of sympathetic blockade of only five minutes and still has a duration in excess of seventeen hours. In addition, it is about …
Investigation Of The Relationship Of The Excited State Geometry Change And The Solvent Dependent Fluorescence Of 9-Methyl Anthroate, Ronald Michael Hoffman
Investigation Of The Relationship Of The Excited State Geometry Change And The Solvent Dependent Fluorescence Of 9-Methyl Anthroate, Ronald Michael Hoffman
Honors Theses
Due to a geometry difference, the polarity of the first excited singlet state of 9-methyl anthroate is shown to be greater than that of the ground state. This polarity difference results in solvent dependent fluorescence properties for this molecule. From the Stokes shift variations of 9-methyl anthroate fluorescence in polar aprotic solvents, the excited state dipole moment is 4.5 D larger than the ground state value. In protic solvents, the Stokes shifts are larger than in polar aprotic solvents indicating a large hydrogen bond contribution to excited state solvation in the former solvents. In non-polar and some polar aprotic solvents, …
Effects Of Dipolar Aprotic Solvents And Ion Pairing On Elimination Reactions, David Andrew Benko
Effects Of Dipolar Aprotic Solvents And Ion Pairing On Elimination Reactions, David Andrew Benko
Honors Theses
An improved method for preparing t-butylacetylene was developed. Starting with t-butyl chloride, aluminum trichloride and vinyl bromide and followed by didehydroalogenation using potassium hydroxide in dimethyl sulfoxide, t-butylacetylene has been prepared in a better than 70% yield. In the process the effect of ion pairing on the orientation of elimination reactions was determined. From this a system for converting 2-haloalkanes directly into 2-alkenes was developed.
Study Of Serotonin And Melatonin In The Bovine Retina, Paul Michael Parker
Study Of Serotonin And Melatonin In The Bovine Retina, Paul Michael Parker
Honors Theses
The purpose of this research was to determine the presence of absence of the indoles serotonin and melatonin in the bovine retina. Their presence in the bovine pineal had been known for some time but no findings have been reported in the literature for bovine retinal tissue. Retinal tissue was extracted according to several procedures suggested by the literature. The extracts were tested against known samples of these indoles by thin layer chromatography and fluorescence spectra examined on the Hitachi-Perkin Elmer MPF-2 Fluorescence Spectrophotometer. The presence of melatonin in the bovine retina was qualitatively determined while not more than 0.01 …
A Study Of Indole-Ring Compounds In The Retina Of The Eye Of The Cow (With Special Emphasis Given To Melatonin And Serotonin), James Howard Kaye
A Study Of Indole-Ring Compounds In The Retina Of The Eye Of The Cow (With Special Emphasis Given To Melatonin And Serotonin), James Howard Kaye
Honors Theses
The literature justifies the hypothesis that there might be either serotonin or melatonin present in the retina of higher vertabrates. Serotonin has been demonstrated in nervous tissues from animals in all parts of the animal kingdom. As the retina is part of the central nervous system, it is a logical place to look for the presence of serotonin. Serotonin has also been found in the brain of ungulate fetuses. Serotonin has been measured in isolated bovine fetal brain some seventy-five to ninety days following gestation.
The Investigation Of The Use Of Fluorescein As A Spectral Probe Of Protein Environment, Michael Andrew Martin
The Investigation Of The Use Of Fluorescein As A Spectral Probe Of Protein Environment, Michael Andrew Martin
Honors Theses
The study was iniated to investigate the properties of fluorescein as a reporter group or spectral probe of protein environment. Through spectral and flourescence studies it was determined that the flourescein binding sites were non-polar relative to bulk water. The spectral study also showed a lowering of pKA for the first one or two flourescein molecules to bind to the protein.
The Cationic Copolymerization Of B-Pinene And Styrene, William David Mciver
The Cationic Copolymerization Of B-Pinene And Styrene, William David Mciver
Honors Theses
The Catatonic polymerization process is least well known of the polymerization mechanisms. Copolymerization by cationic initiation is not well understood. Charles Snyder began investigating the copolymerization of B-pinene and styrene in the fall of 1971, and found some intersting things. He reported, however, that the project was incomplete. This project was based on the work that Snyde began. The products he made, in addition to several others, were completely analyzed in an effort to obtain information about the cationic polymerization process. DSC, GPC, and solvent studies, along with VPO, were the methods of analysis.
Formation Of An Isoquinoline In The Reaction Of A Diazoketone With Boron Trifluoride, Marc Maller
Formation Of An Isoquinoline In The Reaction Of A Diazoketone With Boron Trifluoride, Marc Maller
Honors Theses
It has been reported through work in the field of diazo chemistry that normal reactions of diazo ketones with certain acids can result in some unusual products. In the normal type reaction substituted methyl ketones are the resulting products which occur as a result of the elimination of nitrogen. However, the presence of a nucleophilic center at the ortho position of an aromatic diazo ketone can override the normal replacement and result in a cyclization product with the elimination of nitrogen. In these reactions it was found that addition of excess neoleophile still did not form open-chain products. Both four-and …
The Preparation Of 2,4,4',6,6'-Pentamethyldiborazinyl-1-2' By The Reaction Of B-Trichloroborazine With Grignard Reagent, David C. Sertl
The Preparation Of 2,4,4',6,6'-Pentamethyldiborazinyl-1-2' By The Reaction Of B-Trichloroborazine With Grignard Reagent, David C. Sertl
Honors Theses
The goal of this research was to prepare crystals of 2,3,3',6,6'-pentamethyldibroazinyl1-1,2' in order to obtain vapor pressure data and a gas-phase, infrared spectrum.
Liquid Crystals: Low Melting Nematic 4, 4'-Bis-(Alkylbenzal)-2-Chloro-1,4-Phenylenediamines, Herbert S. Cole Jr.
Liquid Crystals: Low Melting Nematic 4, 4'-Bis-(Alkylbenzal)-2-Chloro-1,4-Phenylenediamines, Herbert S. Cole Jr.
Honors Theses
Several homologues of the 4,4'-bis-(alkoxybenzal)-2-chloro-1,4-phenylene series were synthesized and their mesomorphic behavior characterized. Furthermore a new series of liquid crystalline compounds, 4,4 1 -bis (alkylbenzal)-chloro-l,4-phenylenediamines, have been synthesized and the mesomorphic behavior characterized up to the c carbon chain length. All homologues showed nematic behavior with broad mesophases and particularly low melting points.
Reactions Of Alkyl Halides In Dimethyl Sulfoxide Under Friedel-Crafts Conditions, Robert Wallace Dean Jr.
Reactions Of Alkyl Halides In Dimethyl Sulfoxide Under Friedel-Crafts Conditions, Robert Wallace Dean Jr.
Honors Theses
When dimethyl sulfoxide, ethyl bromide, and 5 mole-percent of ferric chloride are heated together, a yellow precipitate is formed. The product partially decomposes at 172 degrees, with evolution of gas. It is very soluble in water, but only slightly soluble in methanol. It contains 7.18% by weight of iron (III), suggesting a compound of high molecular weight or a mixture. It appears that a Friedel-Crafts alkylation of DMSO has taken place, perhaps giving an ethyldimethyloxosulfonium salt, however, the IR and NMR spectra do not substantiate this. The absence of alkoxydimethylsulfonium salts in the above reaction mixture has been demonstrated. An …