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Articles 1 - 6 of 6
Full-Text Articles in Physical Sciences and Mathematics
Analysis Of Laminar Flow Patterns In Milifluidic Devices, Brian Leger
Analysis Of Laminar Flow Patterns In Milifluidic Devices, Brian Leger
Honors Theses
This research centers around a millifluidic device designed for the analysis of flowing chemical reactions that may happen too quickly to be analyzed by traditional spectroscopic methods. The device works by combining two simple concepts: fluid flows a certain distance over time and chemical reactions progress over time. Combining these allows for the correlation of reaction progress and distance through the device. Since the flow within the device is laminar, there is friction along the walls of the channel that creates a flow profile that elongates over time. The details of the flow were previously unknown but are necessary if …
Modeling The Particle-On-A-Ring Theory In An Undergraduate Laboratory, Courtney Deslauriers
Modeling The Particle-On-A-Ring Theory In An Undergraduate Laboratory, Courtney Deslauriers
Honors Theses
In early chemistry education, students are often taught to think about electrons as small, negatively charged particles existing in planetary orbits around the nucleus of an atom, rather than creating an electron cloud. In reality, electrons exhibit wave-particle duality, and are best described as wave functions. This idea that the electrons travel as waves and are moving around the nucleus so quickly that it is not possible to know the speed or location of an electron at any given moment is extremely abstract and difficult to visualize. This concept is essential to the theory of quantum mechanics, and therefore is …
Porphyrins And Porphyrin Applications, Derek Girouard
Porphyrins And Porphyrin Applications, Derek Girouard
Honors Theses
Porphyrins are a macrocyclic compound that can be modified in a myriad of ways offering useful and unique applications. These applications can range from ion sensing to catalysts in reactions. However, some of the most interesting applications revolve around medical and therapeutic treatments. Porphyrin derivatives can be used in processes known as photodynamic therapy (PDT) and photothermal therapy (PTT) to treat cancerous tumors. Porphyrins have been used in many ways in the body by their attachment to a variety of backbone structures. Porphyrins have potential to be widely utilized in therapeutic treatments as they are further studied and adapted to …
The Evolution Of Deuterium In The Pharmaceutical Industry And Its Effects On Methods Of Deuterium Incorporation, Angela Martinez
The Evolution Of Deuterium In The Pharmaceutical Industry And Its Effects On Methods Of Deuterium Incorporation, Angela Martinez
Honors Theses
The substitution of deuterium, an isotope of hydrogen containing one proton and one neutron, for a hydrogen has far reaching effects on the behavior of the compound. Scientists have been utilizing the effects of deuterium since 1961. The primary purpose for deuterium has been concentrated in the development of internal standards for NMR and mass spectrometers, due to their relative ‘silence’ in these studies, allowing scientists to elucidate mechanisms and trace a compound's movement throughout the body. However, recently, in addition to the use of deuterium as a standard, it has been added to developing or previously created pharmaceutical compounds …
An Investigation Into The History, Science, And Future Of Dental Filling Materials, Natalia Kaczor
An Investigation Into The History, Science, And Future Of Dental Filling Materials, Natalia Kaczor
Honors Theses
No abstract provided.
The Biochemical Characterization Of Cellular Retinoic Acid Binding Protein Type 1 (Crabp1), Emma Magna
The Biochemical Characterization Of Cellular Retinoic Acid Binding Protein Type 1 (Crabp1), Emma Magna
Honors Theses
The goal of this research was to express and purify Cellular Retinoic Acid Binding Protein Type 1 (CRABP1). CRABP1 binds to retinoic acid in the cell and shuttles the retinoic acid from one area in the cell to another. The overproduction of CRABP1 appears to be problematic because it can sequester the retinoic acid and prevent it from regulating gene expression. Previous studies have shown that increased levels of CRABP1 can result in tumor-promoting activity and disruption of lipid biology in the cell. Our objective was to express this protein in an inducible bacterial system, so that we could purify …