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Full-Text Articles in Physical Sciences and Mathematics
Towards Structural Determination Of Human Α1-Glycine Receptor Allostery, Rathna Jyothi Veeramachaneni
Towards Structural Determination Of Human Α1-Glycine Receptor Allostery, Rathna Jyothi Veeramachaneni
Electronic Theses and Dissertations
Recent advances in technology have led to the determination of numerous notable structures of membrane proteins. While they provide valuable information about the structure of membrane proteins these studies often provide static images with potentially limited dynamics, and structural determination often requires truncation of flexible regions, and often utilizes bacterial homologs given the need for stable, heterologous overexpression. In order to better understand allostery at a molecular level, state-dependent crosslinking studies coupled with multidimensional mass spectrometry (MS) were conducted on glycine receptor (GlyR) stabilized in different allosteric states. Predominant allosteric states were stabilized using wild type or mutated receptor in …
Gold And Silver Alloy Nanoparticles: Synthesis, Characterization And Atomic Structure, Chanaka Kapila Kumara
Gold And Silver Alloy Nanoparticles: Synthesis, Characterization And Atomic Structure, Chanaka Kapila Kumara
Electronic Theses and Dissertations
Nanotechnology is an emerging field of science with applications in digital electronics, medicine, catalysis and energy. Gold nanoparticles are nanomaterials that have less than 100 nm at least in one dimension. The composition and the structure/geometry of the nanoparticles determine the chemical properties and reactivity. Modern research focus on method development in atomically monodisperse nanoparticle synthesis. This dissertation describes the method development for synthesis and isolation of atomically precise gold and gold-silver alloy nanoparticles and their comprehensive characterization and atomic structure investigation. Chapter one offers an introduction to the synthesis and isolation methods. These nanoparticles can be represented in the …