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I. A New Synthetic Approach To The Synthesis Of N-(Phosphonoacetyl)-L-Ornithine, Ii. The Influence Of Pyridine On The Ozonolysis Of Alkenes, Bradley M. Johnson
I. A New Synthetic Approach To The Synthesis Of N-(Phosphonoacetyl)-L-Ornithine, Ii. The Influence Of Pyridine On The Ozonolysis Of Alkenes, Bradley M. Johnson
Department of Chemistry: Dissertations, Theses, and Student Research
Part I. The use of chemical inhibitors to manipulate the level of amino acids in cells has proven to be invaluable in the mechanistic study of gene expression in bacteria and fungi. Here we present a new approach to the synthesis of δ‐N‐ (phosphonoacetyl)‐L‐ornithine (PALO), a potent ornithine transcarbamylase inhibitor, using a new amino acid protecting group, 9‐borabicyclononane (9‐BBN). Starting from commercially available reagents and utilizing mild reaction conditions, we were able to form PALO in fewer synthetic steps and in greater yields than previous attempts.
Part II. Ozonolysis is widely used to transform alkenes into oxygen‐rich functional groups (e.g.– …