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Synthesis Of 5-Azaindoles Via A Cycloaddition Reaction Between Nitriles And Donor-Acceptor Cyclopropanes., Mahmoud M Abd Rabo Moustafa, Brian L Pagenkopf
Synthesis Of 5-Azaindoles Via A Cycloaddition Reaction Between Nitriles And Donor-Acceptor Cyclopropanes., Mahmoud M Abd Rabo Moustafa, Brian L Pagenkopf
Chemistry Publications
A new method for the synthesis of 5-azaindole derivatives is reported. A [3+2] dipolar cycloaddition between nitriles and a 3,4-cyclopropanopiperidine followed by SeO(2) oxidation affords the target compounds in moderate to excellent yields. The divergent nature and cost effectiveness of this method makes it very suitable for combinatorial applications in the pharmaceutical industry.