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Full-Text Articles in Physical Sciences and Mathematics
Superhydrophobic Thin Films Fabricated By Reactive Layer-By-Layer Assembly Of Azlactone-Functionalized Polymers, Maren E. Buck, Sarina C. Schwartz, David M. Lynn
Superhydrophobic Thin Films Fabricated By Reactive Layer-By-Layer Assembly Of Azlactone-Functionalized Polymers, Maren E. Buck, Sarina C. Schwartz, David M. Lynn
Chemistry: Faculty Publications
We report an approach to the fabrication of superhydrophobic thin films that is based on the "reactive" layer-by-layer assembly of azlactone-containing polymer multilayers. We demonstrate that films fabricated from alternating layers of the azlactone functionalized polymer poly(2-vinyl- 4,4-dimethylazlactone) (PVDMA) and poly(ethyleneimine) (PEI) exhibit micro- and nanoscale surface features that result in water contact angles in excess of 150°. Our results reveal that the formation of these surface features is (i) dependent upon film thickness (i.e., the number of layers of PEI and PVDMA deposited) and (ii) that it is influenced strongly by the presence (or absence) of cyclic azlactone-functionalized oligomers …
Interaction-Dependent Pcr: Identification Of Ligand-Target Pairs From Libraries Of Ligands And Libraries Of Targets In A Single Solution-Phase Experiment, Lynn M. Mcgregor, David J. Gorin, Christoph E. Dumelin, David R. Liu
Interaction-Dependent Pcr: Identification Of Ligand-Target Pairs From Libraries Of Ligands And Libraries Of Targets In A Single Solution-Phase Experiment, Lynn M. Mcgregor, David J. Gorin, Christoph E. Dumelin, David R. Liu
Chemistry: Faculty Publications
Interaction-dependent PCR (IDPCR) is a solution-phase method to identify binding partners from combined libraries of small-molecule ligands and targets in a single experiment. Binding between DNA-linked targets and DNA-linked ligands induces formation of an extendable duplex. Extension links codes that identify the ligand and target into one selectively amplifiable DNA molecule. In a model selection, IDPCR resulted in the enrichment of DNA encoding all five known protein-ligand pairs out of 67 599 possible sequences.
Nano-Imprinted Thin Films Of Reactive, Azlactone-Containing Polymers: Combining Methods For The Topographic Patterning Of Cell Substrates With Opportunities For Facile Post-Fabrication Chemical Functionalization, Nathaniel J. Fredin, Ryan M. Flessner, Christopher M. Jewell, Shane L. Bechler, Maren E. Buck, David M. Lynn
Nano-Imprinted Thin Films Of Reactive, Azlactone-Containing Polymers: Combining Methods For The Topographic Patterning Of Cell Substrates With Opportunities For Facile Post-Fabrication Chemical Functionalization, Nathaniel J. Fredin, Ryan M. Flessner, Christopher M. Jewell, Shane L. Bechler, Maren E. Buck, David M. Lynn
Chemistry: Faculty Publications
Laser scanning confocal microscopy (LSCM) and atomic force microscopy (AFM) were used to characterize changes in nanoscale structure that occur when ultrathin polyelectrolyte multilayers (PEMs) are incubated in aqueous media. The PEMs investigated here were fabricated by the deposition of alternating layers of plasmid DNA and a hydrolytically degradable polyamine onto a precursor film composed of alternating layers of linear poly(ethylene imine) (LPEI) and sodium poly(styrene sulfonate) (SPS). Past studies of these materials in the context of gene delivery revealed transformations from a morphology that is smooth and uniform to one characterized by the formation of nanometer-scale particulate structures. We …
Immobilization Of Polymer-Decorated Liquid Crystal Droplets On Chemically Tailored Surfaces, Michael I. Kinsinger, Maren E. Buck, Nicholas L. Abbott, David M. Lynn
Immobilization Of Polymer-Decorated Liquid Crystal Droplets On Chemically Tailored Surfaces, Michael I. Kinsinger, Maren E. Buck, Nicholas L. Abbott, David M. Lynn
Chemistry: Faculty Publications
We demonstrate that the assembly of an amphiphilic polyamine on the interfaces of micrometer-sized droplets of a thermotropic liquid crystal (LC) dispersed in aqueous solutions can be used to facilitate the immobilization of LC droplets on chemically functionalized surfaces. Polymer 1 was designed to contain both hydrophobic (alkylfunctionalized) and hydrophilic (primary and tertiary amine-functionalized) side chain functionality. The assembly of this polymer at the interfaces of aqueous dispersions of LC droplets was achieved by the spontaneous adsorption of polymer from aqueous solution. Polymer adsorption triggered transitions in the orientational ordering of the LCs, as observed by polarized light and bright-field …
Functionalization Of Fibers Using Azlactone-Containing Polymers: Layer-By-Layer Fabrication Of Reactive Thin Films On The Surfaces Of Hair And Cellulose-Based Materials, Maren E. Buck, David M. Lynn
Functionalization Of Fibers Using Azlactone-Containing Polymers: Layer-By-Layer Fabrication Of Reactive Thin Films On The Surfaces Of Hair And Cellulose-Based Materials, Maren E. Buck, David M. Lynn
Chemistry: Faculty Publications
We report an approach to the functionalization of fibers and fiber-based materials that is based on the deposition of reactive azlactone-functionalized polymers and the "reactive" layer-by-layer assembly of azlactone-containing thin films. We demonstrate (i) that the azlactone-functionalized polymer poly(2-vinyl-4,4-dimethylazlactone) (PVDMA) can be used to modify the surfaces of a model protein-based fiber (horsehair) and cellulose-based materials (e.g., cotton and paper), and (ii) that fibers functionalized in this manner can be used to support the fabrication of covalently cross-linked and reactive polymer multilayers assembled using PVDMA and poly(ethyleneimine) (PEI). The growth, chemical reactivity, and uniformity of films deposited on these substrates …
Reactive Layer-By-Layer Assembly Of Suspended Thin Films And Semipermeable Membranes At Interfaces Created Between Aqueous And Organic Phases, Maren E. Buck, David M. Lynn
Reactive Layer-By-Layer Assembly Of Suspended Thin Films And Semipermeable Membranes At Interfaces Created Between Aqueous And Organic Phases, Maren E. Buck, David M. Lynn
Chemistry: Faculty Publications
Thin films of polymer suspended across the openings of pores, channels, and microcavities are of interest in a broad range of fundamental and applied contexts. A "reactive" layer-by-layer approach Is demonstrated for the fabrication of suspended thin films and semipermeable membranes that makes use of liquid/ liquid interfaces created between immiscible aqueous and organic phases as templates for film fabrication (see image). (Figure Presented).
Langmuir Films Of Flexible Polymers Transferred To Aqueous/Liquid Crystal Interfaces Induce Uniform Azimuthal Alignment Of The Liquid Crystal, Michael I. Kinsinger, Maren E. Buck, Maria Victoria Meli, Nicholas L. Abbott, David M. Lynn
Langmuir Films Of Flexible Polymers Transferred To Aqueous/Liquid Crystal Interfaces Induce Uniform Azimuthal Alignment Of The Liquid Crystal, Michael I. Kinsinger, Maren E. Buck, Maria Victoria Meli, Nicholas L. Abbott, David M. Lynn
Chemistry: Faculty Publications
We reported recently that amphiphilic polymers can be assembled at interfaces created between aqueous phases and thermotropic liquid crystals (LCs) in ways that: (i) couple the organization of the polymer to the order of the LC and (ii) respond to changes in the properties of aqueous phases that can be characterized as changes in the optical appearance of the LC. This investigation sought to characterize the behavior of aqueous-LC interfaces decorated with uniaxially compressed thin films of polymers transferred by Langmuir-Schaefer (LS) transfer. Here, we report physicochemical characterization of interfaces created between aqueous phases and the thermotropic LC 4-cyano-4′-pentylbiphenyl (5CB) …
Azlactone-Functionalized Polymers As Reactive Templates For Parallel Polymer Synthesis: Synthesis And Screening Of A Small Library Of Cationic Polymers In The Context Of Dna Delivery, Bin Sun, Xianghui Liu, Maren E. Buck, David M. Lynn
Azlactone-Functionalized Polymers As Reactive Templates For Parallel Polymer Synthesis: Synthesis And Screening Of A Small Library Of Cationic Polymers In The Context Of Dna Delivery, Bin Sun, Xianghui Liu, Maren E. Buck, David M. Lynn
Chemistry: Faculty Publications
Azlactone-functionalized polymers are used as reactive templates for the synthesis of a library of amine-functionalized polymers of interest in the context of DNA delivery and other applications.
Free-Standing And Reactive Thin Films Fabricated By Covalent Layer-By-Layer Assembly And Subsequent Lift-Off Of Azlactone-Containing Polymer Multilayers, Maren E. Buck, David M. Lynn
Free-Standing And Reactive Thin Films Fabricated By Covalent Layer-By-Layer Assembly And Subsequent Lift-Off Of Azlactone-Containing Polymer Multilayers, Maren E. Buck, David M. Lynn
Chemistry: Faculty Publications
We report an approach to the fabrication of free-standing and amine-reactive thin films that is based on the reactive layer-by-layer assembly and subsequent lift-off of azlactone-containing polymer multilayers. We demonstrate that covalently cross-linked multilayers fabricated using the azlactone-functionalized polymer poly(2-vinyl-4,4-dimethylazlactone) (PVDMA) and a primary amine-containing polymer [poly(ethyleneimine) (PEI)] can be delaminated from planar glass and silicon surfaces by immersion in mildly acidic aqueous environments to yield flexible freestanding membranes. These free-standing membranes are robust and can withstand exposure to strong acid, strong base, or incubation in high ionic strength solutions that typically lead to the disruption and erosion of polymer …