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Part I: Design And Synthesis Of Novel Drugs To Treat Asthma By Targeting Gabaa Receptors In The Lung Part Ii: Design And Synthesis Of Novel Α2/Α3 Subtype Selective Gabaar Ligands For Cns Disorders, Rajwana Jahan

Theses and Dissertations

Part I. Asthma is a major healthcare challenge affecting an estimated 300 million people globally. Over $56 billion in asthma-related healthcare expenses occur in the United States annually. Moreover, asthma accounts for the majority of missed school/work days, Doctor and emergency room visits, and patient hospitalizations in young persons. Consequently, asthma continues to be a significant healthcare burden in terms of morbidity, productivity, and medical costs. Beta 2-adrenergic agonists and inhaled corticosteroids (ICs) are the most commonly prescribed treatments for the acute and chronic management of asthma. Both agents present efficacy, compliance, and adverse side effect concerns.

Hence, there is …