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Surface Modification Of Pillar Array Systems For Chromatography And Fluorescence Enhancement, Danielle Ruth Lincoln
Surface Modification Of Pillar Array Systems For Chromatography And Fluorescence Enhancement, Danielle Ruth Lincoln
Doctoral Dissertations
Thin-layer chromatography offers many advantages in the world of chemical separations due to its ease of use, high sensitivity, range of applicability, and multiplex capability. However, this technique is succeptible to band broadening effects that limit its efficiency. Attempting to resolve these effects by decreasing particle size causes a decrease in mobile phase velocity which creates its own band broadening via longitudinal diffusion. However, pillar array systems on the micro- and nanoscale have been shown as useful analogues to thin-layer chromatography which mitigate the efficiency concerns associated with the method.
The work within this dissertation is concerned with the modification …