Physical Sciences and Mathematics Commons^™

Novel Mass Spectrometry Methods For The Analysis Of Covalent And Non-Covalent Protein Structures And Their Influence On The Functions Of Therapeutic Proteins, Jake Pawlowski

Doctoral Dissertations

Biotherapeutics consist of biopolymers (proteins, polysaccharides, DNA, and RNA) that are used to treat a wide range of conditions from cancer to autoimmune disease to enzyme replacement. In recent years biotherapeutics have experience tremendous growth due to advances in technology and our understanding of human biology. They are very important to modern medicine due to their ability to treat diseases which are unable to be treated with small molecule-based drugs. Unlike small molecule drugs which are synthetically produced, biotherapeutics are expressed inside cells. Produced biotherapeutics are not made up of a single homogenous population but instead a population of highly …