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Full-Text Articles in Physical Sciences and Mathematics
Effect Of Nanoparticle Surface Charge At The Plasma Membrane And Beyond, Rr Arvizo, Or Miranda, Ma Thompson, Cm Pabelick, R Bhattacharya, Jd Robertson, Vm Rotello, Ys Prakash, P Mukherjee
Effect Of Nanoparticle Surface Charge At The Plasma Membrane And Beyond, Rr Arvizo, Or Miranda, Ma Thompson, Cm Pabelick, R Bhattacharya, Jd Robertson, Vm Rotello, Ys Prakash, P Mukherjee
Vincent Rotello
Herein, we demonstrate that the surface charge of gold nanoparticles (AuNPs) plays a critical role in modulating membrane potential of different malignant and nonmalignant cell types and subsequent downstream intracellular events. The findings presented here describe a novel mechanism for cell-nanoparticle interactions and AuNP uptake: modulation of membrane potential and its effect on intracellular events. These studies will help understand the biology of cell-nanoparticle interactions and facilitate the engineering of nanoparticles for specific intracellular targets.