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Physical Sciences and Mathematics Commons™
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Full-Text Articles in Physical Sciences and Mathematics
Silent, Fluorescent Labeling Of Native Neuronal Receptors, D Vytla, R E. Combs-Bachmann, A M. Hussey, I Hafez, James Chambers
Silent, Fluorescent Labeling Of Native Neuronal Receptors, D Vytla, R E. Combs-Bachmann, A M. Hussey, I Hafez, James Chambers
James Chambers
We have developed a minimally-perturbing strategy that enables labeling and subcellular visualization of endogenous dendritic receptors on live, wild-type neurons. Specifically, calcium-permeable non-NMDA glutamate receptors expressed in hippocampal neurons can be targeted with this novel synthetic tri-functional molecule. This ligand-directed probe was targeted towards AMPA receptors and bears an electrophilic group for covalent bond formation with an amino acid side chain on the extracellular side of the ion channel. This molecule was designed in such a way that the use-dependent, polyamine-based ligand accumulates the chemically-reactive group at the extracellular side of these polyamine-sensitive receptors, thereby allowing covalent bond formation between …
A Positive Feedback Synapse From Retinal Horizontal Cells To Cone Photoreceptors, Skylar L. Jackman, Norbert Babai, James Chambers, Wallace B. Thoreson, Richard H. Kramer
A Positive Feedback Synapse From Retinal Horizontal Cells To Cone Photoreceptors, Skylar L. Jackman, Norbert Babai, James Chambers, Wallace B. Thoreson, Richard H. Kramer
James Chambers
Cone photoreceptors and horizontal cells (HCs) have a reciprocal synapse that underlies lateral inhibition and establishes the antagonistic center-surround organization of the visual system. Cones transmit to HCs through an excitatory synapse and HCs feed back to cones through an inhibitory synapse. Here we report that HCs also transmit to cone terminals a positive feedback signal that elevates intracellular Ca2+ and accelerates neurotransmitter release. Positive and negative feedback are both initiated by AMPA receptors on HCs, but positive feedback appears to be mediated by a change in HC Ca2+, whereas negative feedback is mediated by a change in HC membrane …
Asymmetry In Chemical Structures And In Life: My Last Two Articles, Otto Vogl
Asymmetry In Chemical Structures And In Life: My Last Two Articles, Otto Vogl
Otto Vogl
No abstract provided.
Center Of Umass – Industry Research On Polymers: Cumirp: Inception And Founding, Otto Vogl
Center Of Umass – Industry Research On Polymers: Cumirp: Inception And Founding, Otto Vogl
Otto Vogl
No abstract provided.
Polymer Science And The Arts: Oriental Lacquer, Otto Vogl
Polymer Science And The Arts: Oriental Lacquer, Otto Vogl
Otto Vogl
No abstract provided.