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Full-Text Articles in Physical Sciences and Mathematics
Identifying Natural Inhibitors Of Bacterial Efflux Pumps, Marrisa Therriault
Identifying Natural Inhibitors Of Bacterial Efflux Pumps, Marrisa Therriault
Honors Theses
Antibiotic resistance is a constantly progressing epidemic. Many strains of bacteria have developed a resistance to antibiotics, resulting in prolonged sickness and death. Resistance can be to a specific drug (single drug resistance) or to multiple drugs (multi-drug resistance). This resistance can be caused by a tripartite protein pump called an efflux pump that extends through the inner and outer membranes of the bacterium to pump antibiotics from the inside of the cell to the extracellular environment. In E. coli the efflux pump is called AcrAB-TolC. In the efforts to combat this problem, this experiment focuses on the inactivation of …
Tracking Disparate Colony Morphological Trends With Thermus Scotoductus, Matthew P. Leverick
Tracking Disparate Colony Morphological Trends With Thermus Scotoductus, Matthew P. Leverick
Honors Theses
When plating most mesophilic bacteria, the colony shape, size, and color tends to be uniform when a single strain is present. When plating defined cell densities of T. scotoductus, however, the colonies were not of uniform size and shape while it grew on the surface. In this project, we sought to observe trends in colony morphology (shape and size) changes using the thermophile Thermus scotoductus on nutrient rich agar plates at 60°C. A general planktonic growth curve was also created to help characterize the activity of this bacterium. This project was our first attempt to characterize if this unusual phenomenon …
Analysis And Review Of The Effects Of Bacterial Competition On Efflux Pump Inhibition, Robert Leszcynski
Analysis And Review Of The Effects Of Bacterial Competition On Efflux Pump Inhibition, Robert Leszcynski
Honors Theses
Multidrug resistant antibacterial strains are a dangerous problem for modern medical professionals. When cells of two different strains are grown together, they must compete with each other for nutrients. This competition can lead to the production of harmful compounds that are toxic to the competing strain. One such compound may be a compound that inhibits the efflux of antibiotics from the cell. When the cells compete with one another, one or both of the cells will produce compounds that are harmful to the competing strain.
Boron Dipyrromethenes: Synthesis And Computational Analysis, Eduardo Rivé Lockwood
Boron Dipyrromethenes: Synthesis And Computational Analysis, Eduardo Rivé Lockwood
Honors Theses
Recently, there has been a growing interest in the boron dipyrromethene (BODIPY, 4,4′- difluoro-4-bora-3a,4a-diaza-s-indacene) compounds. BODIPY compounds have fascinating properties that allow for the absorption and emission of light in the near infrared region of the electromagnetic spectrum. These molecules are highly modifiable making them ideal chemicals for the use of photoelectric energy conversion such as for commercial use in dye sensitized solar cells (DSSCs). It has been previously shown that different meso compounds have only a slight effect on the absorptive capabilities of these BODIPY compounds. We believe that the BODIPY compounds’ lack of planarity is one of the …