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- (Trifluoromethyl)trimethylsilane (1)
- Aryl Fluorides (1)
- Binding strengths (1)
- Carbonyl stretching frequency (1)
- Cyanide sensing (1)
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- Difluoromethyl Ketone (1)
- Fluoride Initiator (1)
- Fragmentation behavior (1)
- Meso-tetrakis(pentafluorophenyl)porphyrin (1)
- Meso-tetraphenylporphyrin (1)
- Mono-trifluoromethylation (1)
- Organofluorine Compounds (1)
- PH sensing (1)
- Pyrrole-modified porphyrin (1)
- Silylated Intermediate (1)
- Tetrahedral Intermediate (1)
- Trifluoromethyl Ketone (1)
- Weinreb Amide (1)
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Articles 1 - 2 of 2
Full-Text Articles in Physical Sciences and Mathematics
Transition Metals As Tools To Probe The Electronic Properties Of Porphyrinoids, Jillian Worlinsky
Transition Metals As Tools To Probe The Electronic Properties Of Porphyrinoids, Jillian Worlinsky
Chemistry Education Materials
This thesis describes in a number of separate chapters a range of studies that measure the variation of specific physical properties with structural modification of the macrocycles, with a particular focus also on using their coordinated metals as probes. Specifically, the transition metal ions are used as tools for interrogation of the electronic properties of porphyrins and pyrrole-modified porphyrins. With the aim of better understanding the electronic and structural factors that govern the optical responses, axial binding strengths, fragmentation patterns and carbonyl stretching frequencies of meso-tetraarylporphyrins, a rational design of pyrrole-modified metalloporphyrins with designed optical properties is derived.
Preparation Of Organofluorine Compounds: Exploring Mono-, Di-, And Tri-Fluorination, Diandra M. Rudzinski
Preparation Of Organofluorine Compounds: Exploring Mono-, Di-, And Tri-Fluorination, Diandra M. Rudzinski
Master's Theses
Organofluorine compounds exhibit biological activity and have advantageous properties for drug design. Natural occurring fluorinated molecules are rare, demanding new synthetic methods for their preparation. A novel route to access trifluoromethyl ketones from Weinreb amide precursors is discussed. This is the first documented method for the use of the Ruppert-Prakash reagent, (trifluoromethyl)trimethylsilane, for the production of trifluoromethyl ketones from amide starting materials. This method is tolerant of aryl and alkyl substrates exhibited by their moderate to excellent yields. A discussion of the unusual reactivity of these amides, their selectivity for mono-trifluoromethylation, and other mono-, and di-fluorination attempts are reported.