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Studies Toward The Total Synthesis Of Antascomicin B, David Ross Clay
Studies Toward The Total Synthesis Of Antascomicin B, David Ross Clay
Graduate Theses and Dissertations
The following dissertation describes synthetic efforts toward the synthesis of the C21-C34 fragment of antascomicin B. Our initial enzymatic approach is detailed as well as an asymmetric transfer hydrogenation (ATH) strategy that will be used in the eventual total synthesis of the molecule. Several investigations into anomalies observed during (ATH) reactions are also discussed.