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Full-Text Articles in Physical Sciences and Mathematics
Oga Inhibition By Glcnac-Selenazoline, E. J. Kim, D. C. Love, E. Darout, M. Abdo, B. Rempel, S. G. Withers, Paul R. Rablen, J. A. Hanover, S. Knapp
Oga Inhibition By Glcnac-Selenazoline, E. J. Kim, D. C. Love, E. Darout, M. Abdo, B. Rempel, S. G. Withers, Paul R. Rablen, J. A. Hanover, S. Knapp
Chemistry & Biochemistry Faculty Works
The title compound, which differs from the powerful O-GlcNAcase (OGA) inhibitor GlcNAc-thiazoline only at the chalcogen atom (Se for S), is a much weaker inhibitor in a direct OGA assay. In human cells, however, the selenazoline shows comparable ability to induce hyper-O-GlcNAc-ylation, and the two show similar reduction of insulin-stimulated translocation of glucose transporter 4 in differentiated 3T3 adipocytes. (C) 2010 Elsevier Ltd. All rights reserved.
Conformations Of A Model Protein Revealed By An Aggregating Cuᴵᴵ Porphyrin: Sensing The Difference, G. De Luca, A. Romeo, L. M. Scolaro, Robert F. Pasternack
Conformations Of A Model Protein Revealed By An Aggregating Cuᴵᴵ Porphyrin: Sensing The Difference, G. De Luca, A. Romeo, L. M. Scolaro, Robert F. Pasternack
Chemistry & Biochemistry Faculty Works
Aggregated t-CuP binds to poly-L-glutamate through supramolecular interactions, revealing itself to be an extremely sensitive probe for the major conformations of the polymeric scaffold.