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Full-Text Articles in Physical Sciences and Mathematics
Microbial Natural Products: Molecular Blueprints For Antitumor Drugs, Lesley Ann Giddings, David J. Newman
Microbial Natural Products: Molecular Blueprints For Antitumor Drugs, Lesley Ann Giddings, David J. Newman
Chemistry: Faculty Publications
Microbes from two of the three domains of life, the Prokarya, and Eukarya, continue to serve as rich sources of structurally complex chemical scaffolds that have proven to be essential for the development of anticancer therapeutics. This review describes only a handful of exemplary natural products and their derivatives as well as those that have served as elegant blueprints for the development of novel synthetic structures that are either currently in use or in clinical or preclinical trials together with some of their earlier analogs in some cases whose failure to proceed aided in the derivation of later compounds. In …
Catalytic Methyl Transfer From Dimethylcarbonate To Carboxylic Acids, Yuan Ji, Jessica Sweeney, Jillian Zoglio, David J. Gorin
Catalytic Methyl Transfer From Dimethylcarbonate To Carboxylic Acids, Yuan Ji, Jessica Sweeney, Jillian Zoglio, David J. Gorin
Chemistry: Faculty Publications
Although methylation reactions are commonplace, currently used reagents are hazardous, toxic, and/or unstable. Dimethylcarbonate has been put forth as an inexpensive, nontoxic, and “green” potential methylating reagent. Herein we report a general, base-catalyzed methyl transfer from dimethylcarbonate to carboxylic acids. High selectivity for esterification is observed even in the presence of unprotected phenols, and the mild reaction conditions enable conservation of stereochemistry at epimerizable stereocenters. Isotope-labeling studies suggest a mechanism proceeding by direct methyl transfer from dimethylcarbonate to the substrate.
One-Pot Anti-Markovnikov Hydroamination Of Unactivated Alkenes By Hydrozirconation And Amination, Alexandra E. Strom, John F. Hartwig
One-Pot Anti-Markovnikov Hydroamination Of Unactivated Alkenes By Hydrozirconation And Amination, Alexandra E. Strom, John F. Hartwig
Chemistry: Faculty Publications
A one-pot anti-Markovnikov hydroamination of alkenes is reported. The synthesis of primary and secondary amines from unactivated olefins was accomplished in the presence of a variety of functional groups. Hydrozirconation, followed by amination with nitrogen electrophiles, provides exclusive anti-Markovnikov selectivity. Most products are isolated in high yields without the use of column chromatography.