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Butylated Hydroxytoluene Analogs: Synthesis And Evaluation Of Their Multipotent Antioxidant Activities, Azhar Ariffin
Butylated Hydroxytoluene Analogs: Synthesis And Evaluation Of Their Multipotent Antioxidant Activities, Azhar Ariffin
Azhar Ariffin
A computer-aided predictions of antioxidant activities were performed with the Prediction Activity Spectra of Substances (PASS) program. Antioxidant activity of compounds 1, 3, 4 and 5 were studied using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and lipid peroxidation assays to verify the predictions obtained by the PASS program. Compounds 3 and 5 showed more inhibition of DPPH stable free radical at 10(-4) M than the well-known standard antioxidant, butylated hydroxytoluene (BHT). Compound 5 exhibited promising in vitro inhibition of Fe2+-induced lipid peroxidation of the essential egg yolk as a lipid-rich medium (83.99%, IC50 16.07 +/- 3.51 mu M/mL) compared to alpha-tocopherol (alpha-TOH, 84.6%, IC50 …