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Interactions Between The Azoarcus Ribozyme And Manganese (Ii) Divalent Cations, Joshua Martwick
Interactions Between The Azoarcus Ribozyme And Manganese (Ii) Divalent Cations, Joshua Martwick
University Honors Theses
The RNA world hypothesis suggests that RNA systems were the first form of life on the planet, beginning to appear approximately 4 billion years ago. Group I introns are self-splicing RNA elements in extant organisms and use Mg2+ as the principle divalent cation to promote catalysis. The group I intron ribozyme from Azoarcus is frequently used in origin of life studies, partially due to its autocatalytic abilities - the Azoarcus ribozyme is able to be broken into fragments and reassemble itself into its fully functional ribozyme. Previous work identified metal binding sites on the Azoarcus ribozyme which use both …