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Full-Text Articles in Physical Sciences and Mathematics
The Ion Pair Thermal Model Of Maldi Ms, Shiyue Fang
The Ion Pair Thermal Model Of Maldi Ms, Shiyue Fang
Michigan Tech Publications
The ion pair thermal model for MALDI MS is described. Key elements of the model include thermal desorption and ionization, strong tendency to neutralization via ion pair formation and proton transfer in the gas phase, thermal equilibrium, overall charge neutral plume, and thermal energy assisted free ion generation via ion pair separation by ion extraction potential. The quantities of ions in the solid sample and in the gaseous plume are estimated. Ion yields of different classes of molecules including peptides, nucleic acids, permanent salts and neutral molecules are estimated at the macroscale and single ion pair levels. The estimated ion …
Hydrochloric Acid Modification And Lead Removal Studies On Naturally Occurring Zeolites From Nevada, New Mexico, And Arizona, Garven M. Huntley, Rudy Luck, Michael Mullins, Nick Newberry
Hydrochloric Acid Modification And Lead Removal Studies On Naturally Occurring Zeolites From Nevada, New Mexico, And Arizona, Garven M. Huntley, Rudy Luck, Michael Mullins, Nick Newberry
Michigan Tech Publications
Four naturally occurring zeolites were examined to verify their assignments as chabazites AZLB-Ca and AZLB-Na (Bowie, Arizona) and clinoptilolites NM-Ca (Winston, New Mexico) and NV-Na (Ash Meadows, Nevada). Based on powder X-ray diffraction, NM-Ca was discovered to be mostly quartz with some clinoptilolite residues. Treatment with concentrated HCl (12.1 M) acid resulted in AZLB-Ca and AZLB-Na, the chabazite-like species, becoming amorphous, as confirmed by powder X-ray diffraction. In contrast, NM-Ca and NV-Na, which are clinoptilolite-like species, withstood boiling in concentrated HCl acid. This treatment removes calcium, magnesium, sodium, potassium, aluminum, and iron atoms or ions from the framework while leaving …
Targeting Of Glut5 For Transporter-Mediated Drug-Delivery Is Contingent Upon Substrate Hydrophilicity, Nazanin Nahrjou, Avik Ghosh, Marina Tanasova
Targeting Of Glut5 For Transporter-Mediated Drug-Delivery Is Contingent Upon Substrate Hydrophilicity, Nazanin Nahrjou, Avik Ghosh, Marina Tanasova
Michigan Tech Publications
Specific link between high fructose uptake and cancer development and progression highlighted fructose transporters as potential means to achieve GLUT-mediated discrimination between normal and cancer cells. The gained expression of fructose-specific transporter GLUT5 in various cancers offers a possibility for developing cancer-specific imaging and bioactive agents. Herein, we explore the feasibility of delivering a bioactive agent through cancer-relevant fructose-specific transporter GLUT5. We employed specific targeting of GLUT5 by 2,5-anhydro-D-mannitol and investigated several drug conjugates for their ability to induce cancer-specific cytotoxicity. The proof-of-concept analysis was carried out for conjugates of chlorambucil (CLB) in GLUT5-positive breast cancer cells and normal breast …
Ratiometric Near-Infrared Fluorescent Probes Based On Hemicyanine Dyes Bearing Dithioacetal And Formal Residues For Ph Detection In Mitochondria, Yunnan Yan, Yibin Zhang, Shuai Xia, Shulin Wan, Tara Vohs, Marina Tanasova, Rudy Luck, Haiying Lui
Ratiometric Near-Infrared Fluorescent Probes Based On Hemicyanine Dyes Bearing Dithioacetal And Formal Residues For Ph Detection In Mitochondria, Yunnan Yan, Yibin Zhang, Shuai Xia, Shulin Wan, Tara Vohs, Marina Tanasova, Rudy Luck, Haiying Lui
Michigan Tech Publications
Ratiometric near-infrared fluorescent probes (AH+ and BH+) have been prepared for pH determination in mitochondria by attaching dithioacetal and formal residues onto a hemicyanine dye. The reactive formyl group on probe BH+ allows for retention inside mitochondria as it can react with a protein primary amine residue to form an imine under slightly basic pH 8.0. Probes AH+ and BH+ display ratiometric fluorescent responses to pH changes through the protonation and deprotonaton of a hydroxy group in hemicyanine dyes with experimentally determined pKa values of 6.85 and 6.49, respectively. Calculated pKa values from a variety of theoretical methods indicated that …