Physical Sciences and Mathematics Commons^™

Synthesis Of 2-Acylphenol And Flavene Derivatives From The Ruthenium-Catalyzed Oxidative C-H Acylation Of Phenols With Aldehydes, Hanbin Lee, Chae S. Yi

Chemistry Faculty Research and Publications

The cationic ruthenium hydride complex [(C₆H₆)(PCy₃)(CO)RuH]⁺BF₄⁻ has been found to be an effective catalyst for the oxidative C–H coupling reaction of phenols with aldehydes to give 2-acylphenol compounds. The coupling of phenols with α,β-unsaturated aldehydes selectively gives the flavene derivatives. The catalytic method mediates direct oxidative C–H coupling of phenol and aldehyde substrates without using any metal oxidants or forming wasteful byproducts.