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Full-Text Articles in Physical Sciences and Mathematics
Gas-Phase Formation Of Environmentally Persistent Free Radicals From Thermal Degradation Of Catechol, Hydroquinone, Phenols And Tobacco, Julien Gnonlonfoun Adounkpe
Gas-Phase Formation Of Environmentally Persistent Free Radicals From Thermal Degradation Of Catechol, Hydroquinone, Phenols And Tobacco, Julien Gnonlonfoun Adounkpe
LSU Doctoral Dissertations
Catechol, hydroquinone and Phenol are major constituents of the mainstream tobacco smoke. The toxicity of tobacco has been attributed to the ability of catechol and hydroquinone to undergo endogenous or exogenous redox cycling to form semiquinone type radicals responsible of Reactive Oxygen Species (ROS) formation. ROS such as hydroxyl radicals can cause severe oxidative stress on biological tissues and can provoke severe signaling pathways leading to cardiovascular and pulmonary dysfunctions and carcinogenesis. Given that semiquinone type radicals are organic radicals, characterized by their high instability and reactivity; it is somewhat surprising that they can live long enough mostly when associated …